2回の寛解導入に成功した高齢者 KOR-SA3544 陽性骨髄低形成性急性リンパ球性白血病の1例

Abstract

We report a case of myelohypoplastic acute lymphocytic leukemia (ALL) with KOR-SA3544 positive cells. A 67-year-old man was admitted to our hospital because of pharyngitis. Laboratory data revealed leukopenia (2,000/μl). He was diagnosed as ALL (L2) with KOR-SA3544 as a surface-marker. Prognosis of ALL with KOR-SA3544 positive cells in aged patients is considered not to be good, because KOR- SA3544 is associated with Philadelphia chromosome. He was treated according to the protocol JAL-SG ALL-93 by the combination of Vincristine, Doxorubicin, L- Asparaginase, and Methotrexate. A bone marrow examination after chemotherapy did not show any blastic cells or ALL cells. Thus, in spite of the presence of KOR-SA3544 positive cells, complete remission could be introduced by the treatment. During the treatment, serious side effects did not occur.