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031 Journal of Nara Medical Association >
Vol.52 No.1 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/645
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| Title: | INFLUENCE OF X-RAYS ON TRANSGENERATIONAL LUNG TUMORIGENESIS IN CBA MICE |
| Authors: | Kamino, Kenji |
| Keywords: | CBA/J mice
prezygotlc
testicular
X-ray irradiation
lung tumours
progeny |
| Issue Date: | 28-Feb-2001 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.52 No.1 p.1-8 |
| Abstract: | The aim of the present study was to ascertain whether prezygotic
exposure of male mice to X-rays increases a carcinogenic risk in the progeny. The
testicles of 9-week-old male CBA/J mice were X-ray irradiated (1 Gy or 2 Gy) and the
animals were then mated at 1, 3 and 9 weeks after treatment with untreated virgin 12-
week-old females of the same strain. The 1-Gy offspring (155 males and 127 females), 2-
Gy offspring (111 males and 95 females) and additional control offspring (119 males and
111 females) were kept for life under standard laboratory conditions. The lungs were
investigated for development of adenomas and adenocarcinomas. No significantly
increased tumour incidences were observed in the 1-Gy and 2-Gy offspring groups
compared with the control group. However, with regard to the dignity of the tumours,
the ratios of animals with carcinomas to animals with adenomas were slightly increased
in both irradiation groups of descendants. Although this phenomenon is not statistically
significant, a possibility of enhanced susceptibility to malignant progression of tumours
in the offspring through the paternal germ cell X-irradiation should be considered in
connection with our previous investigation. |
| URI: | http://hdl.handle.net/10564/645 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.52 No.1
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| 01-08p.INFLUENCE OF X-RAYS ON TRANSGENERATIONAL LUNG TUMORIGENESIS IN CBA MICE.pdf | | 1266Kb | Adobe PDF | View/Open |
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