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031 Journal of Nara Medical Association >
Vol.51 No.6 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/640
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| Title: | Fischer 344系ラットにおけるコリン欠乏およびコリン添加アミノ酸食の長期投与による毒性と発癌性 |
| Other Titles: | TOXICOLOGIC AND CARCINOGENIC EFFECTS OF A LONG-TERM ADMINISTRATION OF A CHOLINE-DEFICIENT, L-AMINO ACID-DEFINED DIET OR A CHOLINE-SUPPLEMENTED, L-AMINO ACID-DEFINED DIET IN FISCHER 344 RATS |
| Authors: | 安藤, 信明 |
| Keywords: | choline-deficient L-amino acid-defined diet
choline-supplemented L-ammo acid-defined diet
hepatocarcinogenesis
spontaneous lesions
rats |
| Issue Date: | 31-Dec-2000 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.51 No.6 p.508-525 |
| Abstract: | The present study assessed toxicologic and carcinogenic effects of a long-
term administration of semisynthetic, choline-deficient, L-amino acid-defined (CDAA) and
choline-supplemented, L-amino acid-defined (CSAA) diets in Fischer 344 (F344) rats.
Male and female F344 rats, 5 weeks old, were fed the CDAA or CSAA diet or a conven-
tional laboratory chow, and sacrificed at the end of week 52 and by the end of week 104.
All organs were excised on sacrifice and histologically examined. The following results
were obtained.
1. Hepatocellular carcinomas (HCCs) were induced with high incidence in male rats fed
the CDAA diet. HCC was induced in the background presence of fatty liver and cirrhosis,
through a progression sequence starting from eosinophilic altered hepatocellular focus, then
hepatocellular adenoma, and carcinoma-in-adenoma.
2. HCCs were also induced in female rats fed the CDAA diet with the lower incidence than
in male case.
3. The CDAA diet suppressed the induction of testicular interstitial cell tumors and
pituitary adenomas in males. Both of the CDAA and CSAA diets promoted the induction
of mammary fibroadenomas in females.
4. The CDAA diet induced intestinal lacteal dilatations in both genders, and promoted the
induction of nephropathies in both genders and nephrocalcinoses in males. Both of the
CDAA and CSAA diets promoted the induction of pancreatic altered acinar cell foci plus
acinar cell hyperplasias, forestomach squamous cell hyperplasias and thyroidal C-cell
hyperplasias in both genders and nephrocalcinoses in females.
It is thus indicated that the CDAA diet is hepatocarcinogenic toward both of male and
female F 344 rats and modifies the induction of various spontaneous lesions. In addition, the
CSAA diet can also modify the induction of some spontaneous lesions. Assessments for the
detailed machanisms underlying not only hepatocarcinogenesis but also modification of the
induction of various other lesions are warranted in rats fed the CDAA diet. |
| URI: | http://hdl.handle.net/10564/640 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.51 No.6
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| 508-525p.Fischer 344系ラットにおけるコリン欠乏およびコリン添加.pdf | | 3877Kb | Adobe PDF | View/Open |
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