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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.51 No.6 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/635
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| Title: | NicotinamideのN-nitrosobis(2-oxopropyl)amineによるハムスター膵発癌ポストイニシエーション期の抑制 |
| Other Titles: | INHIBITION BY NICOTINAMIDE OF THE POST-INMATION PHASE OF N-NITROSOBIS(2-OXOPROPYL)AMINE-INDUCED PANCREATIC CARCINOGENESIS IN HAMSTERS |
| Authors: | 三井, 雅之 |
| Keywords: | nicotinamide
pancreatic carcinogenesis
hamster
N-nitrosobis(2-oxopropyl) amine (BOP)
inhibition |
| Issue Date: | 31-Dec-2000 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.51 No.6 p.446-457 |
| Abstract: | Nicotinamide (NA) is synthesized from tryptophan and other amino acids
in human bodies, or supplmented foods as one of vitamins. In this study, the chemo-
preventive effects of NA on pancreatic duct carcinogenesis initiated with N-nitrosobis(2-
oxopropyl)amine (BOP) in Syrian hamsters were investigated. Female 5-week-old ham-
sters were given three weekly subcutaneous injections of BOP at a dose of 10 mg/kg body
weight followed by 0.5% (Group 1) or 0.2% NA (Group 2) in drinking water for 49 weeks.
Additional groups received the BOP injection alone (Group 3), or 0.5% (Group 4) or 0.2%
NA (Group 5) in drinking water without BOP injections. Group 6 served as a non-treated
control. All animals were sacrificed at 52 weeks after the beginning of the experiment and
proliferative lesions in the pancreas were histopathologically assessed. All animals showed
no toxic signs including growth retardation. The incidences and multiplicities of dysplastic
lesions in the exocrine pancreas were significantly lower (p＜0.05) in Groups 1 and 2 than
in Group 3, but NA did not affect the incidence and multiplicity of pancreatic adenocar-
cinomas. Morphometrically, the number and area of islets increased in hamsters given NA.
Pancreatic hepatocytes appeared in the pancreas of hamsters given BOP and NA but there
was no difference in the incidence of these cell populations. In other organs, the incidences
and multiplicity of hyperplasia in the lung were more significantly decreased (p＜0.05) in
Group 1 than in Group 3, and there was statistically more significant increase (p＜0.05) in
the multiplicity of intrahepatic cholangiocellular carcinema in Group 2 than in Group 3.
The present results indicate that pancreatic carcinogenesis was inhibited by NA when
administered during the post-initiation phase of carcinogenesis by BOP in hamsters. |
| URI: | http://hdl.handle.net/10564/635 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.51 No.6
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| 446-457p.NicotinamideのN-nitrosobis(2-oxopropyl)amineによるハムスター膵発癌.pdf | | 2296Kb | Adobe PDF | View/Open |
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