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GINMU >
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031 Journal of Nara Medical Association >
Vol.51 No.6 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/634
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| Title: | N-nitrosobis(2-oxopropyl)amineによるハムスター膵管癌発生に対するtranexamic acid及びphenyl N-tert-butylnitroneの影響 |
| Other Titles: | EFFECTS OF TRANEXAMIC ACID AND PHENYL N-TERT-BUTYLNITRONE ON PANCREATIC CARCINOGENESIS IN HAMSTERS |
| Authors: | 堀口, 浩資 |
| Keywords: | hamster
pancreas
phenyl N-tert-butylnitrone (PBN)
tranexamic acid (TA)
chemoprevention |
| Issue Date: | 31-Dec-2000 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.51 No.6 p.436-445 |
| Abstract: | Effects of tranexamic acid (TA), a plasminogen activator inhibitor, and
phenyl N-tert-butylnitrone (PBN), an inducible nitric oxide synthase (iNOS) inhibitor, on
pancreatic duct carcinogenesis were investigated using a rapid production model for
pancreatic duct carcinoma in hamsters, and the following results were obtained.
1. No toxic signs including growth retardation or loss of pancreatic weights were obser-
ved in hamsters treated with BOP followed by TA or PBN.
2. As pancreatic duct lesions, duct epithelial hyperplasia, atypical hyperplasia and
adenocarcinoma were histologically observed in all of the experimental groups.
3. The diet containing 0.1% TA reduced both the incidence and number of adenocar-
cmomas.
4. The drinking water containing 0.05% PBN did not affect any of the pancreatic lesions
with statistically significant differences.
5. TA or PBN did not affect the PCNA labeling indices of pancreatic ductal lesions.
6. TA reduced inflammatory reactions in the surrounding tissue of pancreatic ductal
lesions, but PBN did not have an effect.
These results indicate that TA possesses inhibitory effects on the development of
pancreatic duct carcinomas, while PBN did not clearly show such effects. |
| URI: | http://hdl.handle.net/10564/634 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.51 No.6
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Files in This Item:
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| 436-445p.N-nitrosobis(2-oxopropyl)amineによるハムスター膵管癌発生.pdf | | 1767Kb | Adobe PDF | View/Open |
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