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GINMU >
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031 Journal of Nara Medical Association >
Vol.51 No.6 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/631
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| Title: | N-Nitrosobis (2-hydroxypropyl) amineによる実験的ラット肺発癌に対する抗菌薬 : clarithromycinとcyclooxygenase-2 inhibitor : etodolacによる抑制効果 |
| Other Titles: | INHIBITORY EFFECTS OF CLARITHROMYCIN AND/OR ETODOLAC ON LUNG CARCINOGENESIS INITIATED BY N-NITROSOBIS (2-HYDROXYPROPYL)AMINE IN RATS |
| Authors: | 村川, 幸市 |
| Keywords: | chronic inflammation
lung carcinogenesis
chemoprevention
BHP
rat |
| Issue Date: | 31-Dec-2000 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.51 No.6 p.407-418 |
| Abstract: | The inhibitory effects of antibiotics and a cyclooxygenase(COX)-2 in-
hibitor on lung carcinogenesis in rats initiated with N-nitrosobis(2-hydroxypropyl)amine
(BHP) were investigated. Male Wistar rats were given tap water without BHP or tap
water containing 2000 ppm BHP with a basal diet for 12 weeks followed by the basal diet
or the diet containing test compounds for 8 weeks. Rats received basal diet or diets
containing 0.02% clarithromycin (CAM), 0.015% etodolac, 0.02% CAM plus 0.015%
etodolac, respectively. The incidences of lung lesions were not different but the numbers of
lesions including adenocarcinoma (AC), squamous cell carcinoma (SCC) and adenos-
quamous carcinoma (ASCC) decreased in rats given CAM, etodolac or CAM plus etodolac
as compared with those in rats given no drugs. In the lungs of rats which received the drugs,
the suppression of chronic inflammation in the alveolar spaces and walls was evident. The
labeling index of proliferating cell nuclear antigen (PCNA) decreased in alveplar hyper-
plasia (AH) in the lungs of rats which received CAM, etodolac and CAM plus etodolac ;
however, 8-hydroxydeoxyguanosine (8-OHdG) generation studied by immunohistochemis-
try did not differ between the lungs of rats with or without the administration of drugs. The
results indicate that the suppression of chronic inflammation may inhibit the progression of
lung carcinogenesis by BHP in rats and possibly provide a chemotherapeutic strategy for
controlling advanced lung cancer. |
| URI: | http://hdl.handle.net/10564/631 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.51 No.6
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Files in This Item:
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| 407-418p.N-Nitrosobis (2-hydroxypropyl) amineによる実験的.pdf | | 10146Kb | Adobe PDF | View/Open |
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