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03 紀要 >
031 Journal of Nara Medical Association >
Vol.51 No.5 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/627
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| Title: | EXPRESSION OF CD80/CD86-CD28 COSTIMULATORY MOLECULES BY PERIPHERAL BLOOD MONONUCLEAR CELLS AND SALIVARY GLANDS OF PATIENTS WITH SJÖGREN'S SYNDROME |
| Authors: | Umemura, Yasuyoshi |
| Keywords: | CD80
CD86
CD28
salivary gland
Sjögren's syndrome |
| Issue Date: | 31-Oct-2000 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.51 No.5 p.381-393 |
| Abstract: | Objective. To investigate the expression of costimulatory molecules CD80,
CD86, and CD28 on peripheral blood monouclear cells (PBMC) and in salivary gland (SG)
biopsy tissues of patients with Sjögren's syndrome (SS).
Methods. Monoclolal antibodies against CD80, CD86, and CD28 were used for flow
cytometry and immunohistochemistry. PBMC CD80, CD86, and CD28 were studied in 21
patients with primary SS and 22 healthy controls, and biopsy tissues were studied in 12
patients with primary SS and 5 with secondary SS (3 with systemic lupus erythematosus
and 2 with rheumatoid arthritis).
Results. CD28 expression on CD4^+ and CD8^+ T cells was lower in SS patients than in
normal controls. CD80 and CD86 were expressed on infiltrating mononuclear cells (MNC)
in SG biopsy specimens ; the majority were adjacent to acini and ducts, with a few MNC in
large lymphoid aggregates. Staining for CD80 and CD86 also revealed positive acinar and
ductal endothelial cells in SG biopsy specimens.
Conclusion. A costimulatory signal CD80 and CD86 may be required for the induction of
lymphoepithelial lesions of SG, but not for progression of SS. CD80 and/or CD86 expressed
on acinar and ductal endothelial cells is associated with activation of T cell in SG tissues
of SS patients. |
| URI: | http://hdl.handle.net/10564/627 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.51 No.5
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| 381-393p.EXPRESSION OF CD80CD86 CD28 COSTIMULATORY MOLECULES BY PERIPHERAL.pdf | | 11861Kb | Adobe PDF | View/Open |
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