慢性閉塞性肺疾患患者の Health-related Quality of Life の決定要因に関する研究

Abstract

To investigate the determinants of Health-related Quality of Life (HRQOL) in patients with chronic obstructive pulmonary disease (COPD), I estimated respiratory function, exercise performance and nutritional status, and related them to HRQOL. I examined baseline checking in 55 stable COPD patients cross-sectionally, and then studied interventional randomized trial with PulmocareTM supplementation. I examined HRQOL with the St. George's Respiratory Questionnaire (SGRQ) and Chronic Respiratory Disease Questionnaire (CRQ), respiratorY function, six minutes walking dis- tance test (6MWD), and nutritional status. I estimated fat free mass with bioelectfical impedence analysis and resting energy expenditure with indirect calorimetry technique for parameter of nutritional status. I intervened in ten cases of COPD with fat-based Pulmocare^TM supplement. After three months supplementation I estimated the parameters. SGRQ activity, impacts, and total score were significantly related to 6MWD. % IBW was also related to SGRQ activity, impacts, and total score. Fat free mass/IBW was related to SGRQ impacts score. Pulmocare^TM (fat-based supplement) reduced significantly RQ (p＜ 0.05) but did not improve respiratory function and HRQOL score. Conclusions : It was suggested that nutritional status is partly related to HRQOL in patients with COPD, and that nutritional supplementation with fat-based supplement decreased RQ.