血清 Surfactant protein A, 血清 Soluble intercellular adhesion molecule-1 測定による石綿肺の病態に関する研究

Abstract

Surfactant protein A (SP-A) and intercellular adhesion molecule-1 (ICAM -1) were recently reported to be associated with fibrotic changes in pulmonary diseases. Inhaled asbestos induces pulmonary fibrosis leading to asbestosis. To evaluate the possible roles for the development of asbestosis, the serum levels of SP-A and sICAM-1 were measured and compared among workers exposed to asbestos (29 patients with asbestosis (PWAs), 50 asbestos-exposed workers without asbestosis (AEWs)), and 51 healthy con- trols (HCs). The mean serum levels of SP-A were significantly higher in PWAs (53.2± 33.4 ng/ml) and AEWs (45.1±30.2 ng/ml) than that in HCs (28.8±10.6 ng/ml). The mean serum levels of SP-A in smoking population of AEWs and HCs were significantly higher than those in non-smoking AEWs and HCs. The mean serum levels of SP-A in smokers were significantly higher in PWAs and AEWs than in HCs. The mean serum levels of SP-A in non-smokers were significantly higher in PWAs than in HCs. The mean serum levels of sICAM-1 were significantly higher in PWAs (270.2±114.8 ng/ml) and AEWs (250.7±80.5 ng/ml) than in HCs (152.2±49.9 ng/ml). The mean serum levels of sICAM -1 in AEWs were significantly higher in smokers than in non-smokers. The mean serum levels of sICAM-1 in smokers were significantly higher in PWAs and AEWs than in HCs. The mean serum levels of sICAM-1 in non-smokers were significantly highter in PWAs and AEWs than in HCs. The serum levels of SP-A were significantly correlated with the serum levels of sICAM-1 in PWAs and AEWs. In conclusion, the present study suggests that asbestos exposure is independently related to the elevation of serum levels of both SP-A and sICAM-1 and that this elevation is associated with the development of asbestosis. SP -A and sICAM-1 can be useful markers in detecting early asbestos-related disorders.