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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.51 No.4 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/609
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| Title: | ENHANCED PLATELET AGGREGABILITY UNDER HIGH SHEAR STRESS IN CORONARY CIRCULATION OF PATIENTS WITH UNSTABLE ANGINA |
| Authors: | Doi, Naofumi |
| Keywords: | coronary circulation
platelet
shear stress
unstable angina
von Willebrand factor |
| Issue Date: | 31-Aug-2000 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.51 No.4 p.214-223 |
| Abstract: | Mechanical forces, including high shear stress, have been found to cause
platelet aggregation. Although increased platelet aggregation is also associated with the
pathophysiology of unstable angina, it is not known whether platelet aggregation induced
by high shear stress occurs in the coronary circulation of patients with unstable angina. We
assayed high shear stress induced platelet aggregation (h-SIPA) in each of 25 patients with
unstable angina and a severe stenotic lesion of the left coronary artery, and in 5 patients
with chest pain syndrome as controls.
We obtained blood from the coronary ostium and coronary sinus of each subject during
angiography and measured h-SIPA of each sample with a modified cone-and-plate type
viscometer set at 108 dyne/cm^2. In the patients with unstable angina, h-SIPA of the
samples from the coronary sinus was significantly higher than in those from the coronary
ostium (p＜0.01). However, we detected no differences between blood from the coronary
ostium and coronary sinus in samples from the control subjects. Although h-SIPA has been
known to be mediated by the interaction between platelets and von Willebrand factor
(vWF), we found no differences in the concentrations of vWF antigen or ristocetin cofactor
activity between plasma from coronary ostium and coronary sinus of the patients with
unstable angina.
Platelet aggregation under conditions of high shear stress is enhanced in the coronary
circulation of patients with unstable angina. These results suggest that treatment of these
patients with an agent that prevents h-SIPA may be beneficial. |
| URI: | http://hdl.handle.net/10564/609 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.51 No.4
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