|
GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.51 No.4 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/608
|
| Title: | Mycobacterium avium complex症患者のCD4^+ αβとγδT細胞機能に関する検討 : 増殖能, IFN-γ, IL-10産生能 |
| Other Titles: | STUDY ON FUNCTIONS OF CD4^+ αβ AND γδ T CELLS IN PATIENTS WITH M, avium COMPLEX DISEASE : PROOLIFERATION AND IFN-γ AND IL-10 PRODUCTION |
| Authors: | 岡村, 英生 |
| Keywords: | non-tuberculous mycobacterial disease
M. avium complex (MAC)
CD4^+ T cell
γδ T cell
cytokine |
| Issue Date: | 31-Aug-2000 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.51 No.4 p.206-213 |
| Abstract: | Several cytokines play a crucial role in host defense immunity against
Mycobacterium tuberculosis. But in patients with non-tuberculous mycobacterial disease,
the function of both CD4^+ αβ T cells and γδ T cells and the cytokine production of these
cells have not yet been assessed. In this study, to elucidate the protective immune
mechanism against M. avium complex (MAC) infection, I examined IFN-γ and IL-10
production in supernatants of coculture of infected monocytes and highly purified CD4^+ T
or γδ T cells obtained from patients and healthy subjects. IFN-γ productions by CD4^+ T
and γδ T cells were significantly higher in healthy subjects than those in patients: mean ng
/ml of IFN-γ in supernatants was 11.90±1.38 in controls and 4.61±3.10 in patients for
CD4^+ T cells (p＜0.01), and 4.41±2.10 in controls and 1.27±1.38 in patients for γδ T cells
(p＜0.001), respectively. CD4^+ T cells produced significantly higher amounts of IFN-γ
than did γδ T cells in patients and healthy subjects (p＜0.01). In remarkable contrast, IL
-10 production in the coculture of infected monocytes and CD4^+ T cells was significantly
higher in patients than in healthy subjeCts: mean pg/ml of IL-10 in supernatants was 220±
105 in patients and 136±39 in controls (p＜0.05), respectively. These results suggest that
the profile of those cytokines produced by CD4^+ T and γδ T cells may be closely related to
pathogenesis of MAC disease. |
| URI: | http://hdl.handle.net/10564/608 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.51 No.4
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| 206-213p.Mycobacterium avium complex症患者のCD4^+ αβとγδT細胞機能に関する検討.pdf | | 844Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
