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031 Journal of Nara Medical Association >
Vol.51 No.3 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/600
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| Title: | Immune-Mediated Cytotoxicity に対するグリチルリチンの作用 |
| Other Titles: | EFFECTS OF GLYCYRRHIZIN ON IMMUNE-MEDIATED CYTOTOXICITY |
| Authors: | 豊原, 眞久 |
| Keywords: | apotosls
glycyrrhizin
cytotoxic T lymphocyte
Fas antlgen
tumor necrosis factor alpha (TNFα) |
| Issue Date: | 30-Jun-2000 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.51 No.3 p.157-168 |
| Abstract: | Intravenous administration of glycyrrhizin (GL) is known to decrease
elevated plasma transaminase levels in patients with chronic viral hepatits, in which
immune-mediated cytotoxicity by cytotoxic T lymphocytes and tumor necrosis factor
alpha (TNFα) is considered to play an important pathogenic role. However, im-
munological interpretation of the transaminase-lowering action by GL is not clear. Studies
were made to elucidate this action immunologically by assessing the effects of GL on
immune-mediated cytotoxicity using an antigen specific murine CD4^+ T cell line, which
exhibits cytotoxicity against antigen presenting cells (APCs) after stimulation with specific
antigen, and two cell lines sensitive to TNFα, a murine fibroblast line and a human
hepatoblastoma line. GL suppressed the cytotoxic activity of the T cells against APCs and
also inhibited TNFα-induced cytotoxicity in both of these TNFα-sensitive cell lines in
vitro. These results suggest that the decrease of elevated transaminase level by GL in
patients with chronic viral hepatitis is mediated in part by inhibition of immune-mediated
cytotoxicity against hepatocyte. |
| URI: | http://hdl.handle.net/10564/600 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.51 No.3
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| 157-168p.Immune-Mediated Cytotoxicity に対するグリチルリチンの作用.pdf | | 1393Kb | Adobe PDF | View/Open |
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