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01121 Journal of Nara Medical Association >
Vol.51 No.3 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/600

Title: Immune-Mediated Cytotoxicity に対するグリチルリチンの作用
Authors: 豊原, 眞久
Keywords: apotosls
cytotoxic T lymphocyte
Fas antlgen
tumor necrosis factor alpha (TNFα)
Issue Date: 30-Jun-2000
Publisher: 奈良医学会
Citation: Journal of Nara Medical Association Vol.51 No.3 p.157-168
Abstract: Intravenous administration of glycyrrhizin (GL) is known to decrease elevated plasma transaminase levels in patients with chronic viral hepatits, in which immune-mediated cytotoxicity by cytotoxic T lymphocytes and tumor necrosis factor alpha (TNFα) is considered to play an important pathogenic role. However, im- munological interpretation of the transaminase-lowering action by GL is not clear. Studies were made to elucidate this action immunologically by assessing the effects of GL on immune-mediated cytotoxicity using an antigen specific murine CD4^+ T cell line, which exhibits cytotoxicity against antigen presenting cells (APCs) after stimulation with specific antigen, and two cell lines sensitive to TNFα, a murine fibroblast line and a human hepatoblastoma line. GL suppressed the cytotoxic activity of the T cells against APCs and also inhibited TNFα-induced cytotoxicity in both of these TNFα-sensitive cell lines in vitro. These results suggest that the decrease of elevated transaminase level by GL in patients with chronic viral hepatitis is mediated in part by inhibition of immune-mediated cytotoxicity against hepatocyte.
URI: http://hdl.handle.net/10564/600
ISSN: 13450069
Appears in Collections:Vol.51 No.3

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