|
GINMU >
02 紀要 >
021 Journal of Nara Medical Association >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/591
|
| Title: | AFP産生胃癌細胞株(FU97)の生物学的特性に関する検討 |
| Other Titles: | BIOLOGICAL BEHAVIOR OF AN ALPHA-FETOPROTEIN-PRODUCING GASTRIC CANCER CELL LINE (FU 97) |
| Authors: | 松田, 雅彦 |
| Keywords: | α-fetoprotein
cultured cell line
gastric cancer
collagen gel culture |
| Issue Date: | 30-Apr-2000 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.51 No.2 p.79-89 |
| Abstract: | A new cell line, designated as FU97, was established from a 66-year-old
gastric cancer patient with a high serum level of α-fetoprotein (AFP). This cell line
produced a large amount of AFP in the conditionated medium as measured by radioim-
munoassary (RIA), and AFP production in situ was also demonstrated by immunohisto-
chemical study. The population doubling time was 95 hours. The cultured cells were
positive for tumorigenicity in athymic nude mice and the histological feature of the
xenografted tumor was similar to that of the tumor primarily isolated from the patient.
The amount of AFP in the xenografted mouse serum, as measured by RIA, increased with
tumor growth. In collagen gel matrix, cultured cells grew with medullary architecture, and
chemosensitivity test was achievable. FU97 is considered to be an AFP-producing gastric
cancer cell line and will provide a useful tool for the study of the production and secretion
of AFP from cells, and also to elucidate the biological activities of AFP. |
| URI: | http://hdl.handle.net/10564/591 |
| ISSN: | 13450069 |
| Appears in Collections: | 021 Journal of Nara Medical Association
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| 079-089p.AFP産生胃癌細胞株(FU97)の生物学的特性に関する検討.pdf | | 2666Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
