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03 紀要 >
031 Journal of Nara Medical Association >
Vol.50 No.6 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/562
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| Title: | PLASMA P-SELECTIN IN CHILDREN WITH HEMOLYTIC UREMIC SYN-DROME CAUSED BY ESCHERICHIA COLI O157 : H7 |
| Authors: | Kamitsuji, Hidekazu
Nonami, Kazuma
Ishikawa, Naoko
Murakami, Tomohiko
Nakayama, Akifumi
Umeki, Yayoi
Nakajima, Mitsuru |
| Keywords: | hemolytic uremic syndrome
verotoxin
P-selectin |
| Issue Date: | 31-Dec-1999 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.50 No.6 p.515-523 |
| Abstract: | Microvascular thrombosis in the kidney plays an important role in the
pathogenesis of hemolytic uremic syndrome (HUS). To evaluate the pathophysiological
significance of the plasma levels of P-selectin, which is releared from activated or damaged
endthelial cells, we measured the plasma concentrations of this protein in children with
HUS associated with verotoxin-producing Escherichia coli (VTEC). In the acute phase of
HUS, plasma levels of P-selectin were significantly higher than those in non-HUS or
healthy controls, and returned to normal range in the recovery phase. The elevated levels
of plasma P-selectin were found to correlate with an increase in soluble thrombomodulin
and thrombin antithrombin Ⅲ complex, implying an association between platelet activation,
endothelial cell injury and activation of the coagulation cascade. However, there was no
definite correlation between P-selectin levels and platelet counts or serum creatinine levels.
From these findings, we concluded that the elevation of elevated circulating P-selectin
levels in HUS associated with VTEC infection is related to endothelial cell injury and
platelet activation as a primary event, and its measurement may be helpful for an early
diagnosis of this disease. |
| URI: | http://hdl.handle.net/10564/562 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.50 No.6
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| 515-523p.PLASMA P-SELECTIN IN CHILDREN WITH HEMOLYTIC UREMIC SYN-DROME CAUSED BY ESCHERICHIA COLI O157 H7.pdf | | 712Kb | Adobe PDF | View/Open |
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