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031 Journal of Nara Medical Association >
Vol.50 No.5 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/540
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| Title: | N-Nitrosobis(2-oxopropyl)amineによるハムスター膵と肝内胆管癌発生に対するN-(4-hydroxyphenyl)retinamideの影響 |
| Other Titles: | EFFECTS OF N-(4-HYDROXYPHENYL)RETINAMIDE ON PANCREATIC AND INTRA-HEPATIC BILE DUCT CARCINOGENESIS BY N-NITROSOBIS(2-OXOPROPYL)AMINE IN HAMSTERS |
| Authors: | 笛木, 修 |
| Keywords: | hamster
pancreas
liver
N-(4-hydroxyphenyl) retinamide(4-HPR)
chemo-preventlon |
| Issue Date: | 31-Oct-1999 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.50 No.5 p.375-385 |
| Abstract: | Effects of N-(4-hydroxyphenyl)retinamide (4-HPR), a synthetic retinoid,
on pancreatic duct and intra-hepatic bile duct carcinogenesis were investigated using a
rapid production of pancreatic duct carcinomas in hamsters and the following results were
obtained.
1. No toxic signs including growth retardation and loss of pancreas and liver weights of
4-HPR were observed.
2. As pancreatic ductal lesions, duct epitherial hyperplasia, atypical hyperplasia and
adenocarcinoma were histologically observed.
3. The diet containing 0.0015% 4-HPR reduced the numbers of atypical hyperplasia,
adenocarcinoma and total ductal lesions.
4. The diet containing 0.01&% and 0.04% 4-HPR increased the incidence and number of
intra-hepatic bile duct carcinoma.
These results indicate that 4-HPR possesses diverse actions inhibiting pancreatic duct
carcinogenesis in low doses, and enhancing intra-hepatic bile duct carcinogenesis in high
doses. |
| URI: | http://hdl.handle.net/10564/540 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.50 No.5
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| 375-385p.N-Nitrosobis(2-oxopropyl)amineによるハムスター膵と肝内胆管癌発生に対するN-(4-hydroxyphenyl)retinamideの.pdf | | 2065Kb | Adobe PDF | View/Open |
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