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GINMU >
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031 Journal of Nara Medical Association >
Vol.50 No.5 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/539
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| Title: | N-nitrosobis(2-hydroxypropyl)amine(BHP)によるラット肺と食道発癌に対するbovine lactoferrinの影響 |
| Other Titles: | EFFECTS OF BOVINE LACTOFERRIN ON LUNG AND ESOPHAGEAL CARCINOGENESIS BY N-NITROSOBIS (2-HYDROXYPROPYL)AMINE (BHP) IN RATS |
| Authors: | 吉田, 順一 |
| Keywords: | bovine lactoferrin (bLF)
N-nitrosobis (2-hydroxypropyl) amine (BHP)
rats
lung
esophagus |
| Issue Date: | 31-Oct-1999 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.50 No.5 p.366-374 |
| Abstract: | Effects of bovine lactoferrin (bLF) on lung and esophageal carcinogenesis
by N-nitrosobis(2-hydroxypropyl)amine (BHP) were studied in rats. Male Wistar rats
received 2000 ppm BHP in drinking water for 12 weeks, followed by 0.5% or 2% bLF for
8 weeks or the same doses of bLF for the entire experimental period of 20 weeks. Lung and
esophageal lesions were histopathologically analyzed. No toxic signs including growth
retardation and decreased amount of food intake of bLF were observed. The diet containing
0.5% bLF given after BHP inhibited lung adenoma development and the diets containing
0.5 or 2% bLF given with BHP for 12 weeks followed by without BHP for 8 weeks reduced
the numbers of alveolar hyperplasias and of lung lesions including alveolar hyperplasia,
squamous metaplasia, adenoma, adenocarcinoma and adenosquamous carcinoma. The
diets containing two doses of bLF did not affect esophagial carcinogenesis. No promoting
effects of bLF on lung and esophagial carcinogenesis by BHP in rats were observed.
These results suggest that bLF is a possible candidate as a chemopreventive agent for
lung carcinogenesis. |
| URI: | http://hdl.handle.net/10564/539 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.50 No.5
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| 366-374p.N-nitrosobis(2-hydroxypropyl)amine(BHP)によるラット肺と食道発癌に対するbovine lactoferrinの影響.pdf | | 2046Kb | Adobe PDF | View/Open |
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