乳癌の化学療法後に骨髄異形成症候群を発症した高齢者末期腎不全の1例

Abstract

A case of chemotherapy-induced myelodysplastic syndrome (MDS) in a 78 -year-old female with pancytopenia is reported. The patient had developed left breast cancer in March 1972. After a mastectomy, she was treated with 5-fluorouracil (5-FU) and mitomycin C without radiotherapy. Mild pancytopenia was detected in January 1998. In April 1998, red cell count was 1,540,000/μl, white cell count was 2,400/μl, and platelet count was 69,000/μl. A bone marrow examination in April 1998 showed normal cellularity with 24% blasts. There were dysplastic changes in the erythroid and granulocyte series, and Auer rods in the cytoplasm. The patient was diagnosed as having therapy-related MDS (RAEB-T). MDS is one of the most serious late complications related to chemotherapy. Although alkylating agents are potentially leukemogenic in patients with therapy related- MDS, in this case MDS developed after treatment with 5-FU and mitomycin C.