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031 Journal of Nara Medical Association >
Vol.50 No.4 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/530
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| Title: | N-NITROSOBIS (2-HYDROXYPROPYL) AMINEによる実験的ラット肺発癌に対する抗生物質, 非ステロイド系抗炎症薬および生薬の併用投与による効果 |
| Other Titles: | EFFICACY OF COMBINED ADMINISTRATION OF ANTIBIOTICS, NONSTEROIDAL ANTI-INFLAMMATORY DRUG AND HERBAL MEDICINES ON LUNG CARCINOGENESIS BY N-NITROSOBIS(2-HYDROXYPROPYL) AMINE IN RATS |
| Authors: | 白岩, 和己 |
| Keywords: | lung carcinogenesis
BHP
chronic inflammation
chemoprevention
rat |
| Issue Date: | 31-Aug-1999 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.50 No.4 p.303-315 |
| Abstract: | The efficacy of combined adrninistration of antibiotics, nonsteroidal anti-
inflammatory drug (NSAID) and herbal medicines on lung carcinogenesis were investigat-
ed in rats treated with N-nitrosobis (2-hydroxypropyl) amine (BHP). This study consisted
of two experiments. In both experiments, rats were given tap water without BHP or tap
water containing 2000 ppm BHP with a basal diet for 12 weeks followed by the basal diet
or the diet containing test compounds for 8 weeks. In experiment 1, rats received basal diet
alone or diets containing 0.02% erythromycin (EM), 0.04% ampicillin (ABPC), 1.5% sho'
-saiko-to, 0.02% EM plus 1.5% sho-saiko-to or 0.04% ABPC plus 1.5% sho-saiko-to,
respectively. The incidences of adenocarcinoma (AC) and non-small cell carcinomas
including AC were completely inhibited in rats given ABPC plus sho-saiko-to, and the
numbers of alveolar hyperplasia (AH) and total lung lesions including AH, adenoma (Ad)
and AC, squamous metaplasia, squamous cell carcinoma (SqC) and adenosquamous car-
cinoma (ASqC) were decreased in rats given ABPC plus sho-saiko-to or EM plus sho-saiko
-to. In experiment 2, rats received basal diet alone or diets containing 0.04% ABPC,
0.006% piroxicam, 0.04% ABPC plus 0.006% piroxicam or 0.04% ABPC plus 0.75% ogon,
respectively. The incidences and numbers of AC and non-small cell carcinomas including
AC were decreased in rats given ABPC plus piroxicam or ABPC plus ogon. The inflamma-
tory reactions in lung lesions were reduced in rats given ABPC plus sho-saiko-to or ABPC
plus piroxicam in experiment 1 or 2. These results suggest that combined administration
of antibiotics and NSAID or herbal medicines inhibits the progression of lung car-
cinogenesis in rats initiated with BHP as a result of suppression of chronic inflammation.
Therefore, the continuous inflammatory reaction may exert itself as a promoting factor. |
| URI: | http://hdl.handle.net/10564/530 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.50 No.4
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