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01 奈良県立医科大学 >
011 医学部 >
0112 紀要 >
01121 Journal of Nara Medical Association >
Vol.50 No.3 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/526
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タイトル: | 糖尿病と下垂体機能障害を合併し,高度の痴呆を呈したKlinefelter症候群の1例 |
その他のタイトル: | A CASE OF KLINEFELTER'S SYNDROME ASSOCIATED WITH DIABETES MELLITUS, PITUITARY GLAND DYSFUNCTION, AND SEVERE DEMENTIA |
著者: | 葛本, 雅之 鎌田, 勝三郎 中江, 恵美子 藤本, 伸一 藤井, 謙裕 椎木, 英夫 藤本, 眞一![](/dspace/image/metalink/link_ja.gif) 金内, 雅夫 土肥, 和紘 |
キーワード: | dementia diabetes mellitus Klinefelter's syndrome pituitary gland dysfunction |
発行日: | 1999年6月30日 |
出版者: | 奈良医学会 |
引用: | Journal of Nara Medical Association Vol.50 No.3 p.277-285 |
抄録: | We report a case of Klinefelter's syndrome associated with diabetes
mellitus, pituitary gland dysfunction, and severe dementia. The patient was a 70-year-old
man who had been under medical treatment for diabetes mellitus for twenty years. In
March 1998, he developed cerebral infarction and symptoms of dementia. Physical exami-
nation revealed projection of both forehead and lower jaw, hypoplasia of the genitals, and
blood flow insufficiency beyond the bilateral popliteal arteries. Chromosomal analysis
showed a 46, XY/46, XX/47, XXY mosaic pattern. HbA1c rose to 8.4% and ΔIRI/ΔBS was
0.02 ng/ml, indicating decreased insulin secretion. A pituitary gland dysfunction compli-
cated the clinical scenario in this patient, the secretion of growth hormone, adrenocor-
ticotropic hormone, prolactin, and cortisol was increased, and that of luteinizing hormone,
follicle-stimulating hormone, and testosterone was decreased. Magnetic resonance images
of the head showed a normal-appearing pituitary gland and cerebral infarction at both the
middle and posterior cerebral artery. Therefore, our patient was considered to have
vascular dementia.
In this report, we discuss the relationship between Klinefelter's syndrome and either
diabetes mellitus or pituitary gland dysfunction. |
URI: | http://hdl.handle.net/10564/526 |
ISSN: | 13450069 |
出現コレクション: | Vol.50 No.3
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