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Vol.50 No.3 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/515

Title: 口腔扁平上皮癌におけるMatrix metalloproteinaseとTissue inhibitor of metalloproteinaseの発現と局在についての検討
Other Titles: EXPRESSION AND LOCALIZATION OF MATRIX METALLOPROTEINASES AND TISSUE INHIBITOR OF METALLOPROTEINASES IN ORAL SQUAMOUS CELL CARCINOMA
Authors: 松岡, 弘樹
美島, 健二
山田, 英二
市島, 國雄
高山, 賢一
山本, 一彦
杉村, 正仁
Keywords: Matrix metalloproteinase (MMP)
Tissue inhibitor of metalloproteinase (TIMP)
Squamous cell carcinoma
Issue Date: 30-Jun-1999
Publisher: 奈良医学会
Citation: Journal of Nara Medical Association Vol.50 No.3 p.201-207
Abstract: Immunohistochemical stainings of matrix metalloproteinase (MMP)-2, 9 and tissue inhibitor of metalloproteinase (TIMP)-1, 2, 3 with specific antibodies in paraffin sections of 14 human oral squamous cell carcinomas and 8 normal tissues were perfomed by labeled streptavidinbiotin method. The expression and localization of mRNA of TIMP-1, 2, 3 were studied by in situ hybridization with digoxigenin (DIG) RNA probe in the same specimens. Positive immunostaining for MMP-2, 9 and TIMP-1 were detected in stromal cells of carcinoma, whereas positive staining for TIMP-3 was detected in both stromal cells and cytoplasms of carcinoma cells. Diffuse expression of MMP-2, 9 was observed in carcinomas with advanced stages. They were not detected in normal tissues. Expressions of TIMP-3 mRNA were observed in 11 out of 14 carcinomas. They were seen in stromal cells and in cytoplasms of cardinoma cells (7/4 in only stromal cells and 4/14 in both stromal cells and carcinoma cells). Carcinomas expressing TIMP-3 mRNA tended to be smaller in size than those which were non-expressing. TIMP-3 mRNA was not detected in normal tissues. Our results suggest that MMP-2, 9 are important for the development of oral squamous cell carcinoma and TIMP-3 is an important inhibitor of it.
URI: http://hdl.handle.net/10564/515
ISSN: 13450069
Appears in Collections:Vol.50 No.3

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