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Vol.49 No.6 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/478

Title: インスリン非依存型糖尿病患者の喫煙習慣と尿細管問質障害
Other Titles: EFFECTS OF SMOKING ON TUBULOINTERSTITIAL INJURY IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES MELLITUS
Authors: 金内, 雅夫
川野, 貴弘
辻本, 伸宏
土肥, 和紘
Keywords: diabetic nephropathy
non-insulin-dependent diabetes mellitus
smoking
tubulointerstitial injury
Issue Date: 31-Dec-1998
Publisher: 奈良医学会
Citation: Journal of Nara Medical Association Vol.49 No.6 p.437-441
Abstract: Cigarette smoking is known to promote the progression of diabetic ne- phropathy, but its effect on tubulointerstitial injury has not been established. We therefore examined the relationship between smoking and urinary excretion of β₂-microglobulin (β₂ MG) and N-acetyl-β-D-glucosaminidase (NAG) in 50 microalbuminuric patients with non -insulin-dependent diabetes mellitus. Total tobacco consumption was measured in pack- years (PY). Subjects were divided into three groups based on PY ; group Ⅰ (non-smokers), group Ⅱ (smokers, < 40 PY), and group Ⅲ (smokers, ≧ 40 PY). No significant difference in urinary albumin excretion or creatinine clearance was observed among these 3 groups. Urinary β₂MG excretion was significantly higher in group Ⅲ than in group Ⅰ, and urinary NAG excretion was significantly higher in group Ⅱ than in group Ⅰ. In conclusion, cigarette smokers manifest tubular proteinuria, suggesting that tobacco smoke may have an adverse effect on the renal tubulointerstitium.
URI: http://hdl.handle.net/10564/478
ISSN: 13450069
Appears in Collections:Vol.49 No.6

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