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03 紀要 >
031 Journal of Nara Medical Association >
Vol.49 No.5 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/471
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| Title: | ANGIOTENSIN Ⅱ ANTAGONIST, TCV-116, PREVENTS CARDIAC HYPERTROPHY AND FIBROSIS IN SPONTANEOUSLY HYPERTENSIVE RAT BY SUPPRESSING SYMPATHETIC NERVE ACTIVITY |
| Authors: | Matsuda, Takashi |
| Keywords: | Angiotensin Ⅱ antagosist
β-adrenergic receptor
cardiac fibrosis
cardiac hypertrophy
spontaneously hypertensive rat |
| Issue Date: | 31-Oct-1998 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.49 No.5 p.373-383 |
| Abstract: | I investigated effects of AⅡ receptor antagosist, (TCV-116) on suppression
of cardiac hypertrophy and fibrosis via sympathetic nerve activity in the spontaneously
hypertensive rat (SHR). Method : SHR was administered orally AⅡ receptor antagonist,
(TCV-116), angiotensin converting enzyme inhibitor, (cilazapril), β-receptor blocker
(metoprolol), and arterial vasodilator, (hydralazine) for 16 or 24 weeks.
Pathophysiological study was performed to evaluate cardiac hypertrophy and fibrosis.
Plasma concentration of catecholamines and density of β-adrenoceptors in cardiac
myocyte were evaluated to determine sympathetic nervous system activity. Result : AⅡ
antagonist and ACE inhibitor prevented cardiac hypertrophy and development of myocar-
dial fibrosis to a greater extent than other agents tested. While β-adrenergic blocker also
suppressed myocardial hypertrophy and fibrosis, its effects were weaker than those of AⅡ
antagonist and ACE inhibitor. Bmax of myocardial adrenergic receptor was significantly
higher in the groups administered with AⅡ antagonist, ACE inhibitor, and β-adrenergic
blocker as compared with hydralazine treated and untreated groups. Bmax of myocardial
adrenergic receptor and plasma concentration of catecholamine level did not differ among
groups receiving AⅡ antagonist, ACE inhibitors and β-adrenergic blocker. Conclusion : A
Ⅱ antagonist and ACE inhibitor suppressed activity of renin-angiotesin system (RAS) and
that of sympathetic nervous system, and AⅡ antagonist and ACE inhibitor may be more
effective than β-adrenergic blocker or hydralazine in preventing cardiac hypertrophy and
fibrosis in SHR. |
| URI: | http://hdl.handle.net/10564/471 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.49 No.5
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| 373-383p.ANGIOTENSIN Ⅱ ANTAGONIST, TCV-116, PREVENTS CARDIAC HYPERTROPHY.pdf | | 1382Kb | Adobe PDF | View/Open |
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