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03 紀要 >
031 Journal of Nara Medical Association >
Vol.49 No.5 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/469
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| Title: | Mycobacterium intracellulare菌体成分によるサイトカイン誘導能に関する研究 |
| Other Titles: | ROLE OF CYTOKINE EXPRESSION TO MYCOBAC71ERIUM INTRACELLULARE LYSATE |
| Authors: | 小林, 厚 |
| Keywords: | Mycobacterium avium comlex (MAC) infection
Mycobacterium intracellulare
cytokines
interleukin-10
interleukin-12 |
| Issue Date: | 31-Oct-1998 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.49 No.5 p.353-364 |
| Abstract: | Cell-mediated immune response is known to play a central role in host
resistance to Mycobacterium avium complex (MAC) infection. However, the mechanims
accounting for the persistent survival of intracellular MAC organisms are not elucidated.
Interleukin (IL)-10 inhibits anti-mycobacterial activity of macrophages, which are consid-
ered to be final effectors against MAC organisms. Clarification of the mechanisms of how
IL-10 is induced in association with MAC infection is important to understand the path-
ogenesis of MAC infection.
The present study was addressed to determine the active moiety in the lysate of M.
intracellulare 31 F 093 T to induce IL-10 production. The fraction with a molecular weight
of 50 k Da and pI 6.8 was found to induce IL-10 production to a great extent and to suppress
IL-12 induction in culture of C57 BL/6 (BcgS) mice spleen cells. Administration of this
fraction into A/J (Bcgr) mice increased spleen weight and the number of viable mycobacter-
ia in the spleen after infection with M. intracellzalare 31 F 093 T. In addition, this treatment
suppressed the formation of gramulomatous lesions in the lung of infected mice.
These findings indicate that a 50 k Da, pI 6.8 fraction extracted from M. intracellzalare 31
F 093 T contains one of the factors contributing to the progression of MAC infection. |
| URI: | http://hdl.handle.net/10564/469 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.49 No.5
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| 353-364p.Mycobacterium intracellulare菌体成分によるサイトカイン誘導能に関する研究.pdf | | 1818Kb | Adobe PDF | View/Open |
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