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01121 Journal of Nara Medical Association >
Vol.49 No.4 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/460

Title: 高度の問質病変を示した糖尿病性腎症の4例
Authors: 金内, 雅夫
西野, 俊彦
川野, 貴弘
池田, 祐貴子
阪口, 江津子
尾崎, 博基
井澤, 鉄之
椎木, 英夫
土肥, 和紘
Keywords: diabetic nephropathy
interstitial lesions
ischemic renal injury
Issue Date: 31-Aug-1998
Publisher: 奈良医学会
Citation: Journal of Nara Medical Association Vol.49 No.4 p.271-277
Abstract: Four male patients with diabetic nephropathy who had no or only mild glomerular lesions but did have severe interstitial lesions are reported. The mean duration of diabetes was 4.3 years. All patients had coronary artery disease and smoked, two had hypertension, and none had diabetic retinopathy. Microalbuminuria was detected in 2 patients, and increases in urinary excretion of β2-microglobulin and/or NAG were obser- ved in 3 patients. Renal biopsy specimens in all 4 patients revealed severe interstitial fibrosis with or without infiltration by mononuclear cells, and arteriolar hyalinosis. Drug -induced nephropathy, pyelonephritis, gouty kidney, hypokalemia and hypercalcemia were excluded. These observations suggested the hypothesis that diabetes mellitus directly affects the development of interstitial lesions associated with ischemic renal injury induced by arterio- and/or arteriolosclerosis.
URI: http://hdl.handle.net/10564/460
ISSN: 13450069
Appears in Collections:Vol.49 No.4

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