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01121 Journal of Nara Medical Association >
Vol.49 No.4 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/460
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Title: | 高度の問質病変を示した糖尿病性腎症の4例 |
Other Titles: | FOUR CASES OF DIABETIC NEPHROPATHY WITH SEVERE INTERSTITIAL LESIONS |
Authors: | 金内, 雅夫 西野, 俊彦 川野, 貴弘 池田, 祐貴子 阪口, 江津子 尾崎, 博基 井澤, 鉄之 椎木, 英夫 土肥, 和紘 |
Keywords: | diabetic nephropathy interstitial lesions ischemic renal injury |
Issue Date: | 31-Aug-1998 |
Publisher: | 奈良医学会 |
Citation: | Journal of Nara Medical Association Vol.49 No.4 p.271-277 |
Abstract: | Four male patients with diabetic nephropathy who had no or only mild
glomerular lesions but did have severe interstitial lesions are reported. The mean duration
of diabetes was 4.3 years. All patients had coronary artery disease and smoked, two had
hypertension, and none had diabetic retinopathy. Microalbuminuria was detected in 2
patients, and increases in urinary excretion of β2-microglobulin and/or NAG were obser-
ved in 3 patients. Renal biopsy specimens in all 4 patients revealed severe interstitial
fibrosis with or without infiltration by mononuclear cells, and arteriolar hyalinosis. Drug
-induced nephropathy, pyelonephritis, gouty kidney, hypokalemia and hypercalcemia were
excluded. These observations suggested the hypothesis that diabetes mellitus directly
affects the development of interstitial lesions associated with ischemic renal injury induced
by arterio- and/or arteriolosclerosis. |
URI: | http://hdl.handle.net/10564/460 |
ISSN: | 13450069 |
Appears in Collections: | Vol.49 No.4
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