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タイトル: β-hydroxybutyrate suppresses pathological changes of blood-induced arthropathy in rats
その他のタイトル: β-ヒドロキシ酪酸はラットにおける血液暴露に起因する関節障害の病理学的変化を抑制する
著者: Kawasaki, Ryohei
Sakata, Asuka
Tatsumi, Kohei
Seiji, Mitani
Maiko, Takeda
Kasuda, Shogo
Matsumoto, Naoki
Harada, Suguru
Soeda, Tetsuhiro
Nishida, Yukiko
Yoshimura, Yasushi
Shima, Midori
キーワード: Bone
Cartilage
Nutritional supplements
発行日: 2024年11月29日金曜日
出版者: Springer Nature
引用: Scientific reports. 2024 Nov, vol.14, no.1, article no.29696
抄録: Arthropathy is a common complication in haemophilia and decreases quality of life. It has been known that concentrations of β-hydroxybutyrate (BHB) in blood are increased by a ketogenic diet, and elevated levels of circulating BHB restricts the progression of inflammation-mediated joint pathological changes. We hypothesized that elevation of blood BHB concentrations could be effective for reducing the progression of bleeding-induced arthropathy by moderating the inflammatory responses of macrophages. In this study, we investigated whether BHB alleviates the arthropathy caused by repeated intra-articular blood injection in rats. To increase blood BHB levels, rats were fed with ketogenic diet. Repeated intra-articular blood injection induced significant joint swelling, whereas ketogenic diet intake significantly increased blood BHB concentrations and ameliorated the joint swelling. The periarticular tissue-fibrosis observed in the control diet intake group appeared to be significantly alleviated in the ketogenic diet intake group. In addition, the IL-1β, which is involved in the progression of arthropathy, levels in the supernatants of blood-exposed macrophages derived from THP-1 cell line were significantly suppressed by BHB supplementation. In summary, BHB moderated the pathological joint changes caused by intra-articular blood exposure.
内容記述: 権利情報:© The Author(s) 2024. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
URI: http://hdl.handle.net/10564/4448
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-024-77074-6
学位授与番号: 24601甲第953号
学位授与年月日: 2025-03-14
学位名: 博士(医学)
学位授与機関: 奈良県立医科大学
出現コレクション:2024年度

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