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01 奈良県立医科大学 >
012 大学院 >
0122 学位請求論文 >
01221 博士論文(医学) >
2024年度 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/4447
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タイトル: | Caprylic Acid Inhibits High Mobility Group Box-1-Induced Mitochondrial Damage in Myocardial Tubes |
その他のタイトル: | カプリル酸は心筋細胞におけるHigh Mobility Group Box-1誘導性ミトコンドリア障害を抑制する |
著者: | Nukaga, Shota Fujiwara-Tani, Rina Nishida, Ryoichi Miyagawa, Yoshihiro Goto, Kei Kawahara, Isao Nakashima, Chie Fujii, Kiyomu Ogata, Ruiko Ohmori, Hitoshi Kuniyasu, Hiroki |
キーワード: | medium-chain fatty acid caprylic acid cachexia myocardial damage mitochondria HMGB1 |
発行日: | 2024年7月24日水曜日 |
出版者: | MDPI |
引用: | International journal of molecular sciences. 2024 Jul, vol.25, no.15, article no.8081 |
抄録: | Myocardial damage significantly impacts the prognosis of patients with cancer; however,
the mechanisms of myocardial damage induced by cancer and its treatment remain unknown. We
previously reported that medium-chain fatty acids (MCFAs) improve cancer-induced myocardial
damage but did not evaluate the differences in effect according to MCFA type. Therefore, this
study investigated the role of inflammatory cytokines in cancer-induced myocardial damage and the effects of three types of MCFAs (caprylic acid [C8], capric acid [C10], and lauric acid [C12]). In a mouse model, the C8 diet showed a greater effect on improving myocardial damage compared with C10 and C12 diets. Myocardial tubes differentiated from H9C2 cardiomyoblasts demonstrated increased mitochondrial oxidative stress, decreased membrane potential and mitochondrial volume,
and inhibited myocardial tube differentiation following treatment with high-mobility group box-1(HMGB1) but not interleukin-6 and tumor necrosis factor-α cytokines. However, HMGB1 treatment combined with C8 improved HMGB1-induced mitochondrial damage, enhanced autophagy, and increased mitochondrial biogenesis and maturation. However, these effects were only partial when combined with beta-hydroxybutyrate, a C8 metabolite. Thus, HMGB1 may play an important role in cancer-related myocardial damage. C8 counteracts HMGB1’s effects and improves cancer-related
myocardial damage. Further clinical studies are required to investigate the effects of C8. |
内容記述: | 権利情報:© 2024 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/10564/4447 |
ISSN: | 1422-0067 |
DOI: | https://doi.org/10.3390/ijms25158081 |
学位授与番号: | 24601甲第952号 |
学位授与年月日: | 2025-03-14 |
学位名: | 博士(医学) |
学位授与機関: | 奈良県立医科大学 |
出現コレクション: | 2024年度
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