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このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10564/4447

タイトル: Caprylic Acid Inhibits High Mobility Group Box-1-Induced Mitochondrial Damage in Myocardial Tubes
その他のタイトル: カプリル酸は心筋細胞におけるHigh Mobility Group Box-1誘導性ミトコンドリア障害を抑制する
著者: Nukaga, Shota
Fujiwara-Tani, Rina
Nishida, Ryoichi
Miyagawa, Yoshihiro
Goto, Kei
Kawahara, Isao
Nakashima, Chie
Fujii, Kiyomu
Ogata, Ruiko
Ohmori, Hitoshi
Kuniyasu, Hiroki
キーワード: medium-chain fatty acid
caprylic acid
cachexia
myocardial damage
mitochondria
HMGB1
発行日: 2024年7月24日水曜日
出版者: MDPI
引用: International journal of molecular sciences. 2024 Jul, vol.25, no.15, article no.8081
抄録: Myocardial damage significantly impacts the prognosis of patients with cancer; however, the mechanisms of myocardial damage induced by cancer and its treatment remain unknown. We previously reported that medium-chain fatty acids (MCFAs) improve cancer-induced myocardial damage but did not evaluate the differences in effect according to MCFA type. Therefore, this study investigated the role of inflammatory cytokines in cancer-induced myocardial damage and the effects of three types of MCFAs (caprylic acid [C8], capric acid [C10], and lauric acid [C12]). In a mouse model, the C8 diet showed a greater effect on improving myocardial damage compared with C10 and C12 diets. Myocardial tubes differentiated from H9C2 cardiomyoblasts demonstrated increased mitochondrial oxidative stress, decreased membrane potential and mitochondrial volume, and inhibited myocardial tube differentiation following treatment with high-mobility group box-1(HMGB1) but not interleukin-6 and tumor necrosis factor-α cytokines. However, HMGB1 treatment combined with C8 improved HMGB1-induced mitochondrial damage, enhanced autophagy, and increased mitochondrial biogenesis and maturation. However, these effects were only partial when combined with beta-hydroxybutyrate, a C8 metabolite. Thus, HMGB1 may play an important role in cancer-related myocardial damage. C8 counteracts HMGB1’s effects and improves cancer-related myocardial damage. Further clinical studies are required to investigate the effects of C8.
内容記述: 権利情報:© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/10564/4447
ISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms25158081
学位授与番号: 24601甲第952号
学位授与年月日: 2025-03-14
学位名: 博士(医学)
学位授与機関: 奈良県立医科大学
出現コレクション:2024年度

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