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01 奈良県立医科大学 >
012 大学院 >
0122 学位請求論文 >
01221 博士論文(医学) >
2024年度 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/4446
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タイトル: | Differential Effects of Three Medium-Chain Fatty Acids on Mitochondrial Quality Control and Skeletal Muscle Maturation |
その他のタイトル: | ミトコンドリア品質管理と骨格筋成熟に対する 3 種類の中鎖脂肪酸の作用の差異 |
著者: | Nishida, Ryoichi Nukaga, Shota Kawahara, Isao Miyagawa, Yoshihiro Goto, Kei Nakashima, Chie Luo, Yi Sasaki, Takamitsu Fujii, Kiyomu Ohmori, Hitoshi Ogata, Ruiko Mori, Shiori Fujiwara-Tani, Rina Kuniyasu, Hiroki |
キーワード: | medium-chain fatty acids mitochondrial quality control mitophagy reactive oxygen species skeletal muscle |
発行日: | 2024年7月9日火曜日 |
出版者: | MDPI |
引用: | Antioxidants. 2024 Jul, vol.13, no.7, article no.821 |
抄録: | Nutritional interventions are one focus of sarcopenia treatment. As medium-chain fatty
acids (MCFAs) are oxidized in the mitochondria and produce energy through oxidative phospho rylation (OXPHOS), they are key parts of nutritional interventions. We investigated the in vitro
effects of three types of MCFA, caprylic acid (C8), capric acid (C10), and lauric acid (C12), in skeletal muscle cells. Compared with C10 and C12, C8 promoted mitophagy through the phosphatase and tensin homolog (PTEN)-induced kinase 1-Parkin pathway and increased the expression of peroxisome proliferator-activated receptor gamma coactivator 1-α and dynamin-related protein 1 to reduce mitochondrial oxidative stress and promote OXPHOS. Furthermore, the expression of myogenic
differentiation 1 and myosin heavy chain increased in myotubes, thus promoting muscle differentia tion and maturation. These results suggest that C8 improves mitochondrial quality and promotes skeletal muscle maturation; in contrast, C10 and C12 poorly promoted mitochondrial quality control and oxidative stress and suppressed energy production. Future animal experiments are required to establish the usefulness of C8 for nutritional interventions for sarcopenia. |
内容記述: | 権利情報:© 2024 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/
4.0/). |
URI: | http://hdl.handle.net/10564/4446 |
ISSN: | 2076-3921 |
DOI: | https://doi.org/10.3390/antiox13070821 |
学位授与番号: | 24601甲第951号 |
学位授与年月日: | 2025-03-14 |
学位名: | 博士(医学) |
学位授与機関: | 奈良県立医科大学 |
出現コレクション: | 2024年度
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