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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4356

Title: Association between the gut microbiome and organic acid profiles in a Japanese population with HIV infection
Other Titles: 日本人HIV感染者集団における腸内細菌叢と有機酸プロファイルの関連性
Authors: Hishiya, Naokuni
Uno, Kenji
Nakano, Akiyo
Konishi, Mitsuru
Higashi, Seiya
Eguchi, Shuhei
Ariyoshi, Tadashi
Matsumoto, Asami
Oka, Kentaro
Takahashi, Motomichi
Suzuki, Yuki
Horiuchi, Saori
Hirai, Nobuyasu
Ogawa, Yoshihiko
Ogawa, Taku
Nakano, Ryuichi
Mikasa, Keiichi
Kasahara, Kei
Yano, Hisakazu
Keywords: HIV
gut microbiota
Roseburia
Prevotella_9
short-chain fatty acid
succinic acid
Issue Date: Jan-2024
Publisher: Elsevier Ltd.
Citation: Journal of Infection and Chemotherapy. 2024 Jan, vol.30, no.1, p.58-66
Abstract: Introduction: An increased incidence of metabolic syndrome has been observed in human immunodeficiency virus (HIV)-infected individuals. In contrast, gut dysbiosis is involved in various pathogeneses, including vascular endothelial disorders. Organic acids, including short-chain fatty acids (SCFAs), are essential for maintaining gut homeostasis. Therefore, this study aimed to explore the gut microbiome profile and organic acids in a Japanese population infected with HIV. Methods: Forty-nine patients with HIV infection on combination antiretroviral therapy (cART) were enrolled and divided into the high and low CD4 groups based on a CD4 cutoff of 350 cells/μL. Stool samples were analyzed by 16S ribosomal RNA next-generation sequencing and high-performance liquid chromatography. The association between the gut microbiome, including bacterial taxa and organic acids, was statistically analyzed. Results: The fecal microbial community composition was significantly different between HIV patients with CD4 counts above and below 350 cells/μL. The relative abundance of Roseburia, Prevotella, Prevotella_9, and [Clostridium]_methylpentosum_group were significantly enriched in the high CD4 group. Fecal succinic acid tended to be more abundant in the low CD4 group, and acetic, propionic, and butyric acids tended to be more abundant in the high CD4 group. Roseburia was positively correlated with butyric acid levels. Prevotella_9 and Prevotella were negatively correlated with succinic acid levels and positively correlated with acetic and propionic acid levels. Conclusions: This study showed intestinal dysbiosis bordering on a CD4 count of 350 in patients with HIV infection undergoing cART. These findings might help in understanding intestinal damage and systemic inflammation in HIV infection.
Description: 本文は発行元が定める公開猶予期間終了後に公開
URI: http://hdl.handle.net/10564/4356
ISSN: 1341-321X
DOI: https://doi.org/10.1016/j.jiac.2023.09.013
Academic Degrees and number: 24601甲第905号
Degree-granting date: 2024-03-14
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2023年度

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