DSpace DSpace Softwareについて English
 

GINMU >
01 奈良県立医科大学 >
012 大学院 >
0122 学位請求論文 >
01221 博士論文(医学) >
2023年度 >

このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10564/4350

タイトル: Pneumococcal meningitis in adults in 2014-2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan
その他のタイトル: 日本における小児PCV13導入後2014年-2018年の成人肺炎球菌性髄膜炎
著者: Fujikura, Hiroyuki
Chang, Bin
Tamura, Kosuke
Watanabe, Hiroshi
Tanabe, Yoshinari
Kuronuma, Koji
Fujita, Jiro
Oshima, Kengo
Maruyama, Takaya
Abe, Shuichi
Kasahara, Kei
Nishi, Junichiro
Kubota, Tetsuya
Kinjo, Yuki
Serizawa, Yusuke
Shimbashi, Reiko
Fukusumi, Munehisa
Shimada, Tomoe
Sunagawa, Tomimasa
Suzuki, Motoi
Oishi, Kazunori
Adult IPD Study Group
キーワード: Diseases
Medical research
Microbiology
発行日: 2022年2月
出版者: Nature Portfolio
引用: Scientific Reports. 2022 Feb, vol.12, no.1, article no.3066
抄録: We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual incidence of pneumococcal meningitis in 2016–2018 was 0.20–0.26 cases/100,000 population. Age (p < 0.001) and case fatality rate (p = 0.003) were significantly lower in patients with meningitis than in those without meningitis. The odds of developing meningitis were higher in asplenic/hyposplenic or splenectomized patients (adjusted odds ratio [aOR] 2.29, 95% CI 1.27–4.14), for serotypes 10A (aOR 3.26, 95% CI 2.10–5.06) or 23A (aOR 3.91, 95% CI 2.47–6.19), but lower for those aged ≥ 65 years (aOR 0.59, 95% CI 0.44–0.81). PCV13 had an indirect effect on nonmeningitis, but its impact on meningitis was limited because of an increase in non-PCV13 serotypes. Of meningitis isolates, 78 (35.1%) and 3 (1.4%) were penicillin G- or ceftriaxone-resistant, respectively. We also confirmed an association of the pbp1bA641C mutation with meningitis (aOR 2.92, 95% CI 1.51–5.65).
内容記述: 権利情報:© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/10564/4350
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-022-06950-w
学位授与番号: 24601甲第899号
学位授与年月日: 2024-03-14
学位名: 博士(医学)
学位授与機関: 奈良県立医科大学
出現コレクション:2023年度

このアイテムのファイル:

ファイル 記述 サイズフォーマット
01甲899本文.pdf甲899本文1.15 MBAdobe PDF見る/開く
02甲899本文の要旨.pdf甲899本文の要旨131.84 kBAdobe PDF見る/開く
03甲899審査要旨.pdf甲899審査要旨231.71 kBAdobe PDF見る/開く

このリポジトリに保管されているアイテムは、他に指定されている場合を除き、著作権により保護されています。

 

Valid XHTML 1.0! Powered by DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard - ご意見をお寄せください