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011 医学部 >
0112 紀要 >
01121 Journal of Nara Medical Association >
Vol.49 No.1 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/423

Authors: Okamoto, Shingo
Mayumi Mimura, Mayumi
Moch, Tadao
Sakamoto, Takemi
Izumi, Yukiko
Matzui, Yuhji
Hosokawa, Akiko
Kuriyama, Shigeki
Fukui, Hiroshi
Keywords: Kallmann's syndrome
hypogonadotropic hypogonadism
gonadotropin therapy
pulsatile LH-RH therapy
KAL gene
Issue Date: 28-Feb-1998
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.49 No.1 p.50-56
Abstract: A 24-year-old male patient with Kallmann's syndrome who fathered two children after gonadotropin therapy is reported here. He was diagnosed with Kallmann's syndrome because of hypothalamic hypogonadism associated with anosmia. The gonadotropin therapy was initiated which involved treatment with human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG). After 3 years of treatment, his secondary sexual characteristics developed to near the adult level and sperm were detected in his semen. Although pulsatile luteinizing hormone releasing hormone (LH -RH) injection using a mini-pump was tried for 4 months, it did not maintain the plasma testosterone at normal levels. At 29 y the patient was switched to gonadotropin therapy. His sperm count reached 6×10(6/mm3, and his wife became pregnant ; they had a female baby. His second child was born when the patient was 32 y. The sequence of the KAL gene was normal in all 14 exons of the patient's DNA. Here we describe the clinical benefits of gonadotropin therapy and LH-RH therapy.
URI: http://hdl.handle.net/10564/423
ISSN: 04695550
Appears in Collections:Vol.49 No.1

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