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021 Journal of Nara Medical Association >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/423
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| Title: | A MALE CASE OF KALLMANN'S SYNDROME : FERTILITY INDUCED BY GONADOTROPIN (hCG/hMG) THERAPY |
| Authors: | Okamoto, Shingo
Mayumi Mimura, Mayumi
Moch, Tadao
Sakamoto, Takemi
Izumi, Yukiko
Matzui, Yuhji
Hosokawa, Akiko
Kuriyama, Shigeki
Fukui, Hiroshi |
| Keywords: | Kallmann's syndrome
hypogonadotropic hypogonadism
gonadotropin therapy
pulsatile LH-RH therapy
KAL gene |
| Issue Date: | 28-Feb-1998 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.49 No.1 p.50-56 |
| Abstract: | A 24-year-old male patient with Kallmann's syndrome who fathered two
children after gonadotropin therapy is reported here. He was diagnosed with Kallmann's
syndrome because of hypothalamic hypogonadism associated with anosmia. The
gonadotropin therapy was initiated which involved treatment with human chorionic
gonadotropin (hCG) and human menopausal gonadotropin (hMG). After 3 years of
treatment, his secondary sexual characteristics developed to near the adult level and sperm
were detected in his semen. Although pulsatile luteinizing hormone releasing hormone (LH
-RH) injection using a mini-pump was tried for 4 months, it did not maintain the plasma
testosterone at normal levels. At 29 y the patient was switched to gonadotropin therapy.
His sperm count reached 6×10(6/mm3, and his wife became pregnant ; they had a female
baby. His second child was born when the patient was 32 y. The sequence of the KAL gene
was normal in all 14 exons of the patient's DNA. Here we describe the clinical benefits of
gonadotropin therapy and LH-RH therapy. |
| URI: | http://hdl.handle.net/10564/423 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | 021 Journal of Nara Medical Association
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| 50-56p.A MALE CASE OF KALLMANN'S SYNDROME.pdf | | 700Kb | Adobe PDF | View/Open |
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