DSpace About DSpace Software 日本語
 

GINMU >
01 奈良県立医科大学 >
011 医学部 >
0112 紀要 >
01121 Journal of Nara Medical Association >
Vol.49 No.1 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/422

Title: 糸球体基底膜にびまん性の菲薄化を示した進行期アルポート症候群の1例
Other Titles: AN UNUSUAL CASE WITH ADVANCED STAGE OF ALPORT'S SYNDROME EXHIBITING DIFFUSE THINNING OF THE GLOMERULAR BASEMENT MEMBRANE
Authors: 井澤, 鉄之
久保, 篤史
岩野, 正之
西野, 俊彦
椎木, 英夫
土肥, 和紘
Keywords: Alport's syndrome
collagen Ⅳ α 5 chain
nephrotic syndrome
thin glomerular basement membrane
Issue Date: 28-Feb-1998
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.49 No.1 p.45-49
Abstract: A 16-year-old boy was admitted to our department because of facial and pretibial edema. Laboratory data revealed moderate renal impairment (Ccr 36.8 ml/min), hypoalbuminemia (2.5g/dl), and hypercholesterolemia (303mg/dl). Audiometry demon- strated bilateral and high tone sensorineural deafness. Renal biopsy showed mesangial proliferation, diffuse tubulo-interstitial damage, and clusters of foam cells. Electron microscopic examination disclosed splitting of the glomerular basement membrane (GBM). Most of the GBM was thin; about 200 nm or less in thickness. Lack of collagen Ⅳ α 5 chain was confirmed by using monoclonal antibody to collagen Ⅳ α 5 chain. Accordingly, the patient was diagnosed as having advanced stage of Alport's syndrome (type Ⅲ) associated with nephrotic syndrome. In general, patients with advanced Alport's syndrome show diffuse thickening of the GBM. Therefore, we think that this patient is an unusual case of clinically advanced Alport's syndrome exhibiting diffuse thinning of the GBM. Here we report the details of this case and discuss the relevant literature.
URI: http://hdl.handle.net/10564/422
ISSN: 04695550
13450069
Appears in Collections:Vol.49 No.1

Files in This Item:

File Description SizeFormat
45-49p.糸球体基底膜にびまん性の菲薄化を示した進行期アルポート症候群の1例.pdf1.12 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback