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01121 Journal of Nara Medical Association >
Vol.73 No.1,2,3 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4187

Title: Carboplatin-Paclitaxel Chemoradiotherapy With 66 Gy For Elderly Patients With Locally Advanced Non-Small-Cell Lung Cancer.
Authors: Miura, Sachiko
Inoue, Kazuya
Hontsu, Shigeto
Tanaka, Hiroaki
Miyauchi, Masaki
Yamaki, Kaori
Inoue, Masayoshi
Asakawa, Isao
Tamamoto, Tetsuro
Hasegawa, Masatoshi
Keywords: Carboplatin-paclitaxel chemoradiotherapy
elderly patients
dose escalation
Issue Date: 30-Jun-2022
Publisher: 奈良医学会
Citation: Journal of Nara Medical Association Vol.73 No.1,2,3 p.21-28 (2022.06)
Abstract: Background/ Aim: The common radiation dose administered with chemoradiotherapy for stage III non-small-cell lung cancer (NSCLC) is 60 Gy. We aimed to examine the feasibility and effectiveness of carboplatin-paclitaxel chemoradiotherapy with 66 Gy for elderly NSCLC patients. Patients and Methods: Forty-five patients with stage III NSCLC were enrolled from 2011 to 2014 at our hospital. They were divided into three groups according to their status and underwent different treatments. Overall survival (OS), progression-free survival (PFS), and local control (LC) were determined. Toxicity was evaluated with NCI-CTCAE ver. 4.0; intergroup differences were analysed statistically. Results: The group receiving carboplatin-paclitaxel chemotherapy with 66 Gy showed the longest median OS (40.4 months), PFS (17.9 months), and LC (44.3 months). Toxicity was acceptable in all groups. Conclusion: For elderly patients with stage III NSCLC, carboplatin-paclitaxel chemoradiotherapy with 66 Gy is suggested to be feasible and effective.
URI: http://hdl.handle.net/10564/4187
ISSN: 13450069
Appears in Collections:Vol.73 No.1,2,3

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