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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4114

Title: Reverse Remodeling and Non-Contrast T1 Hypointense Infarct Core in Patients With Reperfused Acute Myocardial Infarction
Other Titles: 再灌流後急性心筋梗塞患者におけるリバースリモデリングと非造影T1低信号梗塞コア
Authors: Hashimoto, Yukihiro
Soeda, Tsunenari
Seno, Ayako
Okayama, Satoshi
Fukuda, Nozomi
Yano, Hiroki
Iwai, Atsushi
Nogi, Kazutaka
Hirai, Kaeko
Fujimoto, Hajime
Suzuki, Megumi
Iwama, Hajime
Nakai, Takehito
Doi, Naofumi
Saito, Yoshihiko
Keywords: Acute myocardial infarction
Cardiac magnetic resonance imaging
Native T1 mapping
Reverse remodeling
T1 hypointense infarct core
Issue Date: 25-Nov-2022
Publisher: Japanese Circulation Society
Citation: Circulation journal Vol.86 No.12 p.1968-1979 (2022 Nov)
Abstract: Background: Non-contrast T1 hypointense infarct cores (ICs) within infarcted myocardium detected using cardiac magnetic resonance imaging (CMR) T1 mapping may help assess the severity of left ventricular (LV) injury. However, because the relationship of ICs with chronic LV reverse remodeling (LVRR) is unknown, this study aimed to clarify it. Methods and Results: We enrolled patients with reperfused AMI who underwent baseline CMR on day-7 post-primary percutaneous coronary intervention (n=109) and 12-month follow-up CMR (n=94). Correlations between ICs and chronic LVRR (end-systolic volume decrease ≥15% at 12-month follow-up from baseline CMR) were investigated. We detected 52 (47.7%) ICs on baseline CMR by non-contrast-T1 mapping. LVRR was found in 52.1% of patients with reperfused AMI at 12-month follow-up. Patients with ICs demonstrated higher peak creatine kinase levels, higher B-type natriuretic peptide levels at discharge, lower LV ejection fraction at discharge, and lower incidence of LVRR than those without ICs (26.5% vs. 73.3%, P<0.001) at follow-up. Multivariate logistic regression analysis showed that the presence of ICs was an independent and the strongest negative predictor for LVRR at 12-month followup (hazard ratio: 0.087, 95% confidence interval: 0.017–0.459, P=0.004). Peak creatine kinase levels, native T1 values at myocardial edema, and myocardial salvaged indices also correlated with ICs. Conclusions: ICs detected by non-contrast-T1 mapping with 3.0-T CMR were an independent negative predictor of LVRR in patients with reperfused AMI.
Description: 博士(医学)・乙第1529号・令和5年3月15日
© 2022, THE JAPANESE CIRCULATION SOCIETY This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
URI: http://hdl.handle.net/10564/4114
ISSN: 13469843
DOI: https://doi.org/10.1253/circj.CJ-22-0479
Academic Degrees and number: 24601乙第1529号
Degree-granting date: 2023-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2022年度

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