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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.48 No.6 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/410
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| Title: | NITRIC OXIDE SYNTHASE INHIBITOR SUPPRESS THE VASOCONSTRIC-TION DUE TO SEVOFLURANE IN CEREBRAL PIAL ARTERIES LARGER THAN 100μm IN DIAMETER IN CATS |
| Authors: | Syohda, Asao |
| Keywords: | nitric oxide
nitric oxide synthase inhibitor
anesthetics
volatile
sevoflurane
vasoconstriction
pial arteries
cats |
| Issue Date: | 31-Dec-1997 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.48 No.6 p.431-439 |
| Abstract: | Background Nitric oxide (NO) plays an important role in the reactivity of
cerebral circulation to various stimuli. It is still unclear whether NO mediates the effect of
sevoflurane on cerebral circulation. We therefore examined this question by measuring the
diameter of pial arteries with or without exposure to NO synthase inhibitor, N ω-nitro-L
-arginine methyl ester (L-NAME).
Methods The cranial window technique was employed in experiments using seven cats that
received fentanyl and midazolam under mechanical ventilation. Diameters of cerebral pial
arteries were observed through the cranial windows using an incident-light fluorescence
microscope and video-recorded with a silicon-intensified target tube video camera system.
Changes in arterial diameter were measured with an image analyzer after the experiments
were finished. The diameters of pial arteries were measured under four conditions follow-
ing the protocol below : 1) intravenous anesthesia ; 2) intravenous plus sevoflurane anesthe-
sia; then after L-NAME infusion, 3) intravenous anesthesia ; and 4) intravenous plus
sevoflurane anesthesia. Changes in vessel diameter were analyzed.
Results The arteries larger than 100μm were significantly constricted (p<0.05) under
sevoflurane inhalation ; in contrast, after the administration of L-NAME, the arteries were
not significantly affected by sevoflurane inhalation.
Conclusion L-NAME inhibited the vasoconstriction due to sevoflurane inhalation in cere-
bral pial arteries larger than 100μm. In the cerebral pial arteries larger than 100μm in
diameter, NO synthesis was shown to be involved in vasoconstriction due to sevoflurane
inhalation. |
| URI: | http://hdl.handle.net/10564/410 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.48 No.6
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Files in This Item:
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| 431-439p.NITRIC OXIDE SYNTHASE INHIBITOR SUPPRESS.pdf | | 972Kb | Adobe PDF | View/Open |
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