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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4086

Title: Reduced salt intake partially restores the circadian rhythm of bladder clock genes in Dahl salt-sensitive rats.
Other Titles: Life sciences
Authors: Iwamoto, Takashi
Torimoto, Kazumasa
Gotoh, Daisuke
Onishi, Sayuri
Hori, Shunta
Morizawa, Yousuke
Nakai, Yasushi
Miyake, Makito
Fujimoto, Kiyohide
Keywords: Circadian rhythm
Clock gene
Inbred Dahl rats
Issue Date: 1-Oct-2022
Publisher: Elsevier
Citation: Life sciences Vol.306 Article No.120842 (2022 Oct)
Abstract: Aims: To examine the circadian expression changes in bladder clock genes in Dahl salt-sensitive rats following high salt intake. Main methods: Eighteen rats were divided into three groups: the high-salt diet group (HS group), the normal-salt diet group (NS group), and the salt-load interruption group (from a 4 % salt diet to a normal diet; salt-load interruption group [SI group]). Each rat was placed in an individual metabolic cage for 24 h twice weekly. Water intake, urine production, voiding frequency, and voided volume per micturition were recorded. Furthermore, 108 control rats were prepared. Bladders were harvested every 4 h at six time points. Furthermore, the mRNA expression of clock genes and mechanosensors was analyzed. Key findings: In the HS group, the bladder clock genes showed lower mRNA levels than in the NS group. The amplitude of circadian expression changes in bladder clock genes in the HS group was lower than that in the NS group. However, after changing from a 4 % salt diet to a normal diet, the waveforms of the clock gene expression in the SI group were closer to those of the NS group. The 24-h water intake and urinary volume of the SI group decreased to levels comparable to those of the NS group. Significance: Reduced salt intake partially restored the circadian rhythms of bladder clock genes.
Description: 博士(医学)・甲第857号・令和4年12月22日
Copyright © 2022 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/10564/4086
ISSN: 00243205
Academic Degrees and number: 24601A857
Degree-granting date: 2022-12-22
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2022年度

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