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Vol.48 No.6 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/403

Title: ラット背部皮弁の生着に及ぼすブクラデシンナトリウム軟膏の影響
Other Titles: THE EFFECT OF DIBUTYRYL CYCLIC AMP OINTMENT ON RAT DORSAL SKIN FLAP SURVIVAL
Authors: 大野, 治彦
波床, 光男
多田, 百合恵
桑原, 理充
柴, 亜伊子
多田, 英之
岡崎, 正
村松, 勉
白井, 利彦
Keywords: DBcAMP
flap survival
biochemistry
Issue Date: 31-Dec-1997
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.48 No.6 p.362-367
Abstract: Dibutyryl cyclic AMP (DBcAMP) ointment has a possibility of successfully increasing flap survival through its pharmacological effects. In this study, the authors investigated the effect of DBcAMP ointment (containing 3%, 5%, 7% DBcAMP) on flap survival, and measured biochemical products (lactate, nor-adrenalin, creatine kenase and lactate dehydrogenase) in the flap tissue using rat dorsal skin flap. The mean length of the surviving flaps in the animals receiving 5% DBcAMP was longer than those in other animal groups. In all portions of the flap, the mean level of lactate in the tissues of the rats reseiving 5% DBcAMP was lower than those in other groups. Thus, use of the ointment containing an appropriate dose of DBcAMP may successfully enhance flap survival. The fact that the length of surviving flap was negatively correlated with the quantity of lactate in the flap tissues suggests that DBcAMP ointment might increase local blood circulation in the flap.
URI: http://hdl.handle.net/10564/403
ISSN: 04695550
13450069
Appears in Collections:Vol.48 No.6

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