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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4019

Title: Ultrasonic Heating Detects Lipiodol Deposition within Liver Tumors after Transarterial Embolization: An In Vivo Approach.
Other Titles: 超音波加温による動脈塞栓後の肝腫瘍内部のリピオドール集積検出能に関する生体内での検討
Authors: Saito, Natsuhiko
Tanaka, Toshihiro
Minamiguchi, Kiyoyuki
Taiji, Ryosuke
Nishiofuku, Hideyuki
Matsumoto, Takeshi
Hirai, Toshiko
Kichikawa, Kimihiko
Kawahara, Naoki
Matsuda, Daiki
Akiyama, Iwaki
Keywords: ultrasonic heating
temperature coefficient of the sound velocity
TACE
TAE
Lipiodol
liver tumor
Issue Date: 12-Sep-2021
Publisher: MDPI
Citation: Biology Vol.10 No.9 Article No.901 (2021 Sep)
Abstract: Computed tomography (CT) is the standard method to evaluate Lipiodol deposition after transarterial embolization (TAE) for a long period. However, iodine but not Lipiodol can be observed on CT. A minimally invasive other method to detect Lipiodol has been needed to evaluate accurate evaluation after procedure. The purpose of this study was to evaluate the efficacy of using the rate of change in sound velocity caused by ultrasonic heating to reflect Lipiodol accumulation after TAE in a rat liver tumor model. We analyzed the association of this developed technique with CT images and histological findings. Eight rats bearing N1S1 cells were prepared. After confirmation of tumor development in a rat liver, Lipiodol was injected via the hepatic artery. Seven days after TAE, CT scan and sound velocity changes caused by ultrasonic heating were measured, and then the rats were sacrificed. An ultrasonic pulse-echo method was used to measure the sound velocity. The temperature coefficient of the sound velocity in each treated tumor was evaluated and compared with the mean CT value and the histological Lipiodol accumulation ratio. Pearson's correlation coefficients were calculated to assess the correlation between the measured values. The correlation coefficient (r) of the mean CT value and histological Lipiodol accumulation ratio was 0.835 (p = 0.010), which was considered statistically significant. Also, those of the temperature coefficient of the sound velocity and the histological Lipiodol accumulation ratio were statistically significant (r = 0.804; p = 0.016). To our knowledge, this is the first study that reported the efficacy of ultrasonic heating to detect Lipiodol accumulation in rat liver tumors after TAE. Our results suggest that the rate of change in sound velocity caused by ultrasonic heating can be used to evaluate Lipiodol accumulation in liver tumors after TAE, and thus could represent an alternative to CT in this application. This new innovative technique is easy to treat and less invasive in terms of avoiding radiation compared with CT.
Description: 博士(医学)・甲第836号・令和4年3月15日
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/10564/4019
ISSN: 20797737
DOI: https://doi.org/10.3390/biology10090901
Academic Degrees and number: 24601A836
Degree-granting date: 2022-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2021年度

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