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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4017

Title: Serum Soluble OX40 as a Diagnostic and Prognostic Biomarker for Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms.
Other Titles: 血清可溶性 OX40 値は薬剤性過敏症症候群の診断および予後予測の指標となりうる。
Authors: Mitsui, Yasuhiro
Shinkuma, Satoru
Nakamura-Nishimura, Yuki
Ommori, Rie
Ogawa, Kohei
Miyagawa, Fumi
Mori, Yasuko
Tohyama, Mikiko
Asada, Hideo
Keywords: CD134
DIHS
DRESS
HHV-6
OX40
Thymus and activation-regulated chemokin
Issue Date: Feb-2022
Publisher: Elsevier
Citation: The journal of allergy and clinical immunology. In practice Vol.10 No.2 p.558-565.e4. (2022 Feb)
Abstract: Background: Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse drug reaction commonly associated with the reactivation of human herpesvirus 6 (HHV-6). There are currently no adequate biomarkers for the early diagnosis and detection of DIHS/DRESS. Notably, OX40 (CD134) has an important role in allergic inflammation and functions as a cellular receptor for HHV-6 entry. We previously reported that the membrane-bound form of OX40 in CD4⁺ T cells was upregulated in DIHS/DRESS. Objective: We sought to investigate the clinical significance of serum soluble OX40 (sOX40) in DIHS/DRESS. Methods: Serum sOX40 levels in patients with DIHS/DRESS (n = 39), maculopapular exanthema/erythema multiforme (n = 17), Stevens-Johnson syndrome/toxic epidermal necrolysis (n = 13), or autoimmune bullous diseases (n = 5), and levels in healthy volunteers (n = 5) were examined by enzyme-linked immunosorbent assay. Copy numbers of HHV-6, HHV-7, and cytomegalovirus in peripheral blood mononuclear cells were quantified using real-time PCR. Results: Serum sOX40 levels in patients with DIHS/DRESS in the acute stage were elevated in parallel with high OX40 expression on CD4⁺ T cells. Serum sOX40 levels were significantly positively correlated with disease severity and serum levels of thymus and activation-regulated chemokine, IL-5, and IL-10. Human herpesvirus 6-positive patients had higher sOX40 levels than did HHV-6-negative patients, and serum sOX40 levels were correlated with HHV-6 DNA loads. Conclusions: Serum sOX40 levels can be a useful diagnostic marker for DIHS/DRESS that reflect disease severity. Elevated serum sOX40 levels also predict HHV-6 reactivation in patients with DIHS/DRESS.
Description: 博士(医学)・甲第834号・令和4年3月15日
Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/10564/4017
ISSN: 22132198
Academic Degrees and number: 24601A834
Degree-granting date: 2022-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2021年度

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