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01 奈良県立医科大学 >
012 大学院 >
0122 学位請求論文 >
01221 博士論文(医学) >
2021年度 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/4013
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タイトル: | Immunohistochemical Expression Status of p53, CD44v9, and Ki-67 in a Series of Fallopian Tube Lesions of High-grade Serous Carcinoma. |
その他のタイトル: | 高異型度漿液性癌における、卵管前癌病変のp53, CD44v9, Ki-67の免疫組織化学的発現態度 |
著者: | Sugimoto, Sumire Uchiyama, Tomoko Kawahara, Naoki Ohbayashi, Chiho![](/dspace/image/metalink/link_ja.gif) Kobayashi, Hiroshi![](/dspace/image/metalink/link_ja.gif) |
キーワード: | TP53 CD44v9 Ki-67 Serous tubal intraepithelial carcinoma (STIC) High-grade serous carcinoma (HGSC) |
発行日: | 2021年9月 |
出版者: | Lippincott Williams & Wilkins |
引用: | International journal of gynecological pathology Vol.40 No.5 p.419-426 (2021 Sep) |
抄録: | Pelvic high-grade serous carcinoma (HGSC) has been postulated to arise via a stepwise accumulation of (epi)genetic alterations from normal epithelium to secretory cell outgrowth (SCOUT), p53 signature, and serous tubal intraepithelial carcinoma (STIC) to invasive HGSC. The aim of this study is to investigate alterations in p53 and CD44v9 expression and the status of Ki-67 labeling index in a series of fallopian tube lesions of HGSC patients. A total of 45 specimens were analyzed in 16 patients with HGSC, and their lesions were categorized as follows: morphologically normal fallopian tube epithelium (FTE, n=6 samples), SCOUT (n=5), p53 signature (n=4), dormant STIC (n=8), active STIC (n=6), and HGSC (n=16). Morphologic features and immunohistochemical expression patterns of the p53 protein, CD44v9 protein, and Ki-67 antigen were blindly evaluated by 2 pathologists. Increased nuclear p53 protein accumulation was observed in p53 signature, dormant STIC, active STIC and HGSC compared with normal FTE and SCOUT (P<0.001). Immunohistochemistry scores of CD44v9 protein expression were significantly higher in normal FTE, SCOUT, and p53 signature than in dormant STIC, active STIC, and HGSC (P<0.001). Both active STIC and HGSC had significantly higher Ki-67 labeling indices than normal FTE, SCOUT, p53 signature and dormant STIC (P<0.001). CD44v9 loss contributes to the stepwise progression of p53 signature to dormant STIC. In conclusion, p53 mutation followed by CD44v9 loss may be involved in the evolution of STIC, which may confer positive clonal selection with a growth and survival advantage. |
内容記述: | 博士(医学)・甲第830号・令和4年3月15日 Copyright © 2021 by the International Society of Gynecological Pathologists. This article has been accepted for publication in International journal of gynecological pathology, 2021 following
peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1097/PGP.0000000000000738. 発行元が定める登録猶予期間終了の後、本文を登録予定(2022.09) |
URI: | http://hdl.handle.net/10564/4013 |
ISSN: | 02771691 |
DOI: | https://doi.org/10.1097/pgp.0000000000000738 |
学位授与番号: | 24601A830 |
学位授与年月日: | 2022-03-15 |
学位名: | 博士(医学) |
学位授与機関: | 奈良県立医科大学 |
出現コレクション: | 2021年度
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