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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4004

Title: Anti-Stem Cell Property of Pterostilbene in Gastrointestinal Cancer Cells.
Other Titles: 消化器がん細胞におけるpterostilbeneの抗幹細胞作用
Authors: Mori, Shiori
Kishi, Shingo
Honoki, Kanya
Fujiwara-Tani, Rina
Moriguchi, Takuma
Sasaki, Takamitsu
Fujii, Kiyomu
Tsukamoto, Shinji
Fujii, Hiromasa
Kido, Akira
Tanaka, Yasuhito
Luo, Yi
Kuniyasu, Hiroki
Keywords: pterostilbene
cancer
stemness
oxidative stress
Issue Date: 8-Dec-2020
Publisher: MDPI
Citation: International journal of molecular sciences Vol.21 No.24 Article No.9347 (2020 Dec)
Abstract: Pterostilbene (PTE) is a natural sterbenoid contained in blueberries that has an antioxidant effect. In contrast, PTE also generates oxidative stress in cancer cells and provides an antitumor effect. Here, we examined the potential mechanism of this contrasting effect of PTE using three gastrointestinal cancer cell lines, namely CT26, HT29, and MKN74. PTE showed a dose-dependent inhibition of cell proliferation, sphere-forming ability, and stem cell marker expression in all three cell lines. Furthermore, the cells treated with PTE showed an increase in mitochondrial membrane potential and an increase in mitochondrial oxidative stress and lipid peroxide. Upon concurrent treatment with vitamin E, N-acetyl-L-cysteine, and PTE, the PTE-induced mitochondrial oxidative stress and growth inhibition were suppressed. These findings indicate that PTE induces oxidative stress in cancer cells, suppresses stemness, and inhibits proliferation. These antitumor effects of PTE are considered to be useful in cancer treatment.
Description: 博士(医学)・甲第821号・令和4年3月15日
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/10564/4004
ISSN: 14220067
DOI: https://doi.org/10.3390/ijms21249347
Academic Degrees and number: 24601A821
Degree-granting date: 2022-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2021年度

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