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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4003

Title: Evaluation of cancer-derived myocardial impairments using a mouse model.
Other Titles: マウスモデルを用いたがん性心筋障害の評価
Authors: Miyagawa, Yoshihiro
Nukaga, Shota
Mori, Takuya
Fujiwara-Tani, Rina
Fujii, Kiyomu
Mori, Shiori
Goto, Kei
Kishi, Shingo
Sasaki, Takamitsu
Nakashima, Chie
Ohmori, Hitoshi
Kawahara, Isao
Luo, Yi
Kuniyasu, Hiroki
Keywords: cachexia
oxidative stress
Issue Date: 13-Oct-2020
Publisher: Impact Journals
Citation: Oncotarget Vol.11 No.41 p.3712-3722 (2020 Oct)
Abstract: Myocardial damage in cancer patients is emphasized as a cause of death; however, there are not many murine cachexia models to evaluate cancer-derived heart disorder. Using the mouse cachexia model that we established previously, we investigated myocardial damage in tumor-bearing mice. In cachexic mice, decreased heart weight and myocardial volume, and dilated left ventricular lumen, and atrophied cardiomyocytes were noted. The cardiomyocytes also showed accumulated 8-hydroxydeoxyguanosine, decreased leucine zipper and EF-hand-containing transmembrane protein-1, and increased microtubule-associated protein light chain3-II. Levels of tumor necrosis factor-α and high-mobility group box-1 proteins in the myocardium were increased, and nuclear factor κB, a signaling molecule associated with these proteins, was activated. When rat cardiomyoblasts (H9c2 cells) were treated with mouse cachexia model ascites and subjected to flux analysis, both oxidative phosphorylation and glycolysis were suppressed, and the cells were in a quiescent state. These results are in good agreement with those previously reported on cancerous myocardial damage. The established mouse cachexia model can therefore be considered useful for analyzing cancer-derived myocardial damage.
Description: 博士(医学)・甲第820号・令和4年3月15日
Copyright: © 2020 Miyagawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0 https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/10564/4003
ISSN: 19492553
DOI: https://doi.org/10.18632/oncotarget.27759
Academic Degrees and number: 24601A820
Degree-granting date: 2022-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2021年度

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