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01 奈良県立医科大学 >
012 大学院 >
0122 学位請求論文 >
01221 博士論文(医学) >
2021年度 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/4003
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タイトル: | Evaluation of cancer-derived myocardial impairments using a mouse model. |
その他のタイトル: | マウスモデルを用いたがん性心筋障害の評価 |
著者: | Miyagawa, Yoshihiro Nukaga, Shota Mori, Takuya Fujiwara-Tani, Rina Fujii, Kiyomu Mori, Shiori Goto, Kei Kishi, Shingo Sasaki, Takamitsu Nakashima, Chie Ohmori, Hitoshi Kawahara, Isao Luo, Yi![](/dspace/image/metalink/link_ja.gif) Kuniyasu, Hiroki![](/dspace/image/metalink/link_ja.gif) |
キーワード: | cachexia myocardium atrophy mitochondria oxidative stress |
発行日: | 2020年10月13日 |
出版者: | Impact Journals |
引用: | Oncotarget Vol.11 No.41 p.3712-3722 (2020 Oct) |
抄録: | Myocardial damage in cancer patients is emphasized as a cause of death; however, there are not many murine cachexia models to evaluate cancer-derived heart disorder. Using the mouse cachexia model that we established previously, we investigated myocardial damage in tumor-bearing mice. In cachexic mice, decreased heart weight and myocardial volume, and dilated left ventricular lumen, and atrophied cardiomyocytes were noted. The cardiomyocytes also showed accumulated 8-hydroxydeoxyguanosine, decreased leucine zipper and EF-hand-containing transmembrane protein-1, and increased microtubule-associated protein light chain3-II. Levels of tumor necrosis factor-α and high-mobility group box-1 proteins in the myocardium were increased, and nuclear factor κB, a signaling molecule associated with these proteins, was activated. When rat cardiomyoblasts (H9c2 cells) were treated with mouse cachexia model ascites and subjected to flux analysis, both oxidative phosphorylation and glycolysis were suppressed, and the cells were in a quiescent state. These results are in good agreement with those previously reported on cancerous myocardial damage. The established mouse cachexia model can therefore be considered useful for analyzing cancer-derived myocardial damage. |
内容記述: | 博士(医学)・甲第820号・令和4年3月15日 Copyright: © 2020 Miyagawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0 https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | http://hdl.handle.net/10564/4003 |
ISSN: | 19492553 |
DOI: | https://doi.org/10.18632/oncotarget.27759 |
学位授与番号: | 24601A820 |
学位授与年月日: | 2022-03-15 |
学位名: | 博士(医学) |
学位授与機関: | 奈良県立医科大学 |
出現コレクション: | 2021年度
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