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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3951

Title: Long-term prognosis of patients undergoing radiofrequency catheter ablation for atrial fibrillation: comparison between heart failure subtypes based on left ventricular ejection fraction.
Other Titles: 心不全を合併した心房細動患者のカテーテルアブレーション後の長期予後 : 左室駆出率に基づいた心不全のサブタイプ間における比較
Authors: Fujimoto, Hajime
Doi, Naofumi
Okayama, Satoshi
Naito, Masaki
Kobori, Atsushi
Kaitani, Kazuaki
Inoue, Koichi
Kurotobi, Toshiya
Morishima, Itsuro
Yamaji, Hirosuke
Matsui, Yumie
Nakazawa, Yuko
Kusano, Kengo
Hirai, Kaeko
Nakai, Takehito
Suzuki, Megumi
Yano, Hiroki
Sakai, Satoshi
Kimura, Takeshi
Shizuta, Satoshi
Saito, Yoshihiko
Keywords: Atrial fibrillation
Catheter ablation
Heart failure
Ejection fraction
Issue Date: 31-Aug-2021
Publisher: Oxford University Press
Citation: Europace Vol.24 No.4 p.576-586 (2022 Apr)
Abstract: Aims: Heart failure (HF) prognosis has been reported similar in patients with preserved vs. reduced left ventricular ejection fraction (LVEF). This study compared the long-term prognosis of HF patients undergoing radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). Methods and results: Among 5010 patients undergoing RFCA in Kansai Plus AF registry, 656 patients (13.1%) with a documented history of HF were enrolled in the study before RFCA. The primary endpoint was a composite of all-cause death, HF hospitalization, and stroke or systemic embolism. Patients with reduced (<40%), mid-range (40-49%), and preserved (≥50%) LVEF were 98 (14.9%), 107 (16.3%), and 451 (68.8%) patients, respectively. The prevalence of ischaemic heart disease and cardiomyopathies was higher among patients with reduced as compared with preserved LVEF (27.6% vs. 10.0%, P < 0.05 and 36.7% vs. 15.3%, P < 0.05, respectively). The median follow-up period was 2.9 years. The 3-year cumulative risk for the primary endpoint was higher in patients with reduced LVEF (32.7%) compared to those with mid-range (11.7%) or preserved (11.6%) LVEF (P < 0.001). Reduced LVEF was the most significant independent risk factor for primary endpoint (hazard ratio, 2.83; 95% confidence interval 1.74-4.61, P < 0.001). The 3-year arrhythmia recurrence rate was similar among the groups (48.2%, 42.8%, and 47.3%, respectively, P = 0.75). Conclusion : This study raises hypothesis that patients with HFrEF and AF had approximately three times higher risk for a composite of all-cause death, HF hospitalization, and stroke or systemic embolism after AF ablation compared with patients with HFmrEF or HFpEF.
Description: 博士(医学)・甲第802号・令和3年12月21日
Copyright: © Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021.
This is a pre-copyedited, author-produced version of an article accepted for publication in Europace following peer review. The version of record "Europace Online ahead of print (2021 Aug 31;euab201) is available online at: https://doi.org/10.1093/europace/euab201.
URI: http://hdl.handle.net/10564/3951
ISSN: 10995129
Academic Degrees and number: 24601A802
Degree-granting date: 2021-12-21
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2021年度

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