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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3934

Title: Evaluation of background parenchymal enhancement in breast contrast-enhanced ultrasound with Sonazoid. ®
Other Titles: 乳房ソナゾイド造影超音波における背景乳腺の造影効果についての検討
Authors: Haga, Masayo
Hirai, Toshiko
Nakai, Tokiko
Kobayashi, Toyoki
Nakamura, Takashi
Marugami, Aki
Ito, Takahiro
Takewa, Megumi
Marugami, Nagaaki
Kichikawa, Kimihiko
Keywords: Breast
US
Background parenchymal enhancement (BPE)
Sonazoid®
Pathology
Issue Date: Oct-2020
Publisher: Springer Nature
Citation: Journal of medical ultrasonics Vol.47 No.4 p.591-601 (2020 Oct)
Abstract: Purpose: The objective of this study was to retrospectively evaluate the association between background parenchymal enhancement (BPE) on contrast-enhanced ultrasound (CEUS) with Sonazoid® and patient characteristics. Additionally, background parenchymal tissues with the high-contrast effect were pathologically observed compared to those showing the low-contrast effect. Methods: A total of 65 patients who underwent breast CEUS with Sonazoid® between January 2010 and November 2013 were enrolled. Regions of interest (ROIs) were put on the tumor and on the background parenchymal tissue. The dB values during the nonenhanced time and at peak contrast enhancement were measured based on the time intensity curve (TIC) drawn by the ROI. The differences in the dB values of pre- and post-enhanced time were obtained separately for ROIs on the tumor and ROIs on the parenchymal tissue. The patient characteristics studied were age, menstrual status, mammographic density, BPE on magnetic resonance imaging (MRI), and pathological diagnoses of breast tumors. Results: There was a weak negative correlation between BPE on CEUS and age. As for the contrast effect of parenchymal tissue, there was a significant difference between the menstruating and menopausal groups. There was no significant difference among the levels of mammographic density, and among the degrees of contrast effect on MRI. BPE on CEUS was the same between those with a malignant tumor and those with a benign tumor in each menstrual status. The parenchymal tissue with the low-contrast effect showed pathological atrophy. Conclusion: The degree of BPE on CEUS appeared related to age, menstruating or menopausal, and atrophy of breast tissue. BPE on CEUS was the same between those with a malignant tumor and those with a benign tumor in each menstrual status.
Description: 博士(医学)・乙第1508号・令和3年3月15日
© Springer Nature Singapore Pte Ltd. 2020.
© The Japan Society of Ultrasonics in Medicine 2020.
This is a post-peer-review, pre-copyedit version of an article published in Journal of medical ultrasonics. The final authenticated version is available online at: https://doi.org/10.1007/s10396-020-01052-4.
URI: http://hdl.handle.net/10564/3934
ISSN: 13464523
DOI: https://doi.org/10.1007/s10396-020-01052-4
Academic Degrees and number: 24601B1508
Degree-granting date: 2021-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2020年度

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