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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3933

Title: Daily salt intake is associated with leg edema and nocturnal urinary volume in elderly men.
Other Titles: 高齢男性における塩分摂取量と下肢浮腫、夜間頻尿との関連について
Authors: Yoshikawa, Motokiyo
Torimoto, Kazumasa
Hirayama, Akihide
Kiba, Keisuke
Yamamoto, Yutaka
Akashi, Yasunori
Shimizu, Nobutaka
Tanaka, Nobumichi
Uemura, Hirotsugu
Fujimoto, Kiyohide
Keywords: edema
leg
nocturia
sodium
urine
Issue Date: Jun-2020
Publisher: Wiley
Citation: Neurourology and urodynamics Vol.39 No.5 p.1550-1556 (2020 Jun)
Abstract: Aims: There is accumulating evidence that excessive salt intake contributes to nocturnal polyuria. We aimed to investigate the relationship between salt intake, leg edema, and nocturnal urine volume (NUV) to assess the etiology of nocturnal polyuria. Methods: A total of 56 men aged ≥60 years who were hospitalized for benign prostatic hyperplasia or with suspected prostatic cancer were enrolled. Urine frequency-volume charts of the patients were maintained, and they underwent bioelectrical impedance analysis twice daily (at 5:00 pm and 6:00 am) and examination of blood (brain natriuretic peptide levels) and urine (sodium and creatinine levels and osmotic pressure) samples once daily (at 6:00 am). Free-water clearance, solute clearance, and sodium clearance at night were measured, and daily salt intake was estimated. Results: The data of 52 patients were analyzed. Daily salt intake positively correlated with leg edema at 5:00 pm, differences in leg extracellular fluid levels between 5:00 pm and 6:00 am, and NUV, but not with diurnal urine volume. Partial correlation coefficients showed that salt intake was a factor of the correlation between NUV and change in extracellular volume in the legs between 5:00 pm and 6:00 am. A multivariate logistic model showed that sleep duration and sodium clearance were independent predictive factors for nocturnal polyuria. Conclusions: Sodium intake correlates with diurnal leg edema and NUV in elderly men. These results provide evidence supporting sodium restriction as an effective treatment for nocturnal polyuria.
Description: 博士(医学)・乙第1507号・令和3年3月15日
© 2020 Wiley Periodicals LLC.
This is the peer reviewed version of the following article: https://onlinelibrary.wiley.com/doi/10.1002/nau.24401, which has been published in final form at https://doi.org/10.1002/nau.24401. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
URI: http://hdl.handle.net/10564/3933
ISSN: 07332467
DOI: https://doi.org/10.1002/nau.24401
Academic Degrees and number: 24601B1507
Degree-granting date: 2021-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2020年度

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