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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3924

Title: Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis.
Other Titles: 乳癌術前化学療法において腋窩リンパ節転移が陰性化するための効果予測因子の検討
Authors: Yokotani, Tomoyo
Ikeda, Naoya
Hirao, Tomoko
Tanaka, Yukimi
Morita, Kohei
Fujii, Tomomi
Ohbayashi, Chiho
Nakamura, Takashi
Kobayashi, Toyoki
Sho, Masayuki
Keywords: Tumor-infiltrating lymphocytes
Axillary dissection
Breast cancer
Neoadjuvant chemotherapy
Axillary pathological complete response
Issue Date: Apr-2021
Publisher: Springer Nature
Citation: Surgery today Vol.51 No.4 p.595-604 (2021 Apr)
Abstract: Purpose: We investigated the role of tumor-infiltrating lymphocytes (TILs) in pretreatment primary breast cancer to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with clinical node-positive disease (cN +). Methods: The subjects of this study were 60 patients with cN + , who received NAC followed by breast surgery with axillary lymph node dissection (ALND). We conducted a semi-quantitative assessment of TILs in pretreatment primary tumors and their association with clinicopathological factors and axillary lymph node metastasis. Results: We observed a higher number of TILs in tumors with negative hormone receptors, positive human epidermal growth factor receptor 2, or high Ki67. TILs were associated with a favorable response to NAC in primary tumors. The rate of axillary pathologic complete response (Ax-pCR) was significantly higher in patients with a high number of TILs than in patients with a low number of TILs (72.0% versus 17.1%, p < 0.001). In multivariable analysis, a high number of TILs was a significant predictor of Ax-pCR as well as of pCR of the primary tumor after NAC. Importantly, all patients with HER2-positive tumors in the high TILs group showed Ax-pCR on ALND. Conclusion: TILs in pretreatment primary breast cancer had the potential to predict therapeutic efficacy of NAC in patients with clinical node-positive disease.
Description: 博士(医学)・乙第1498号・令和3年3月15日
© Springer Nature Singapore Pte Ltd. 2020
This is a post-peer-review, pre-copyedit version of an article published in Surgery today. The final authenticated version is available online at: https://doi.org/10.1007/s00595-020-02157-6.
URI: http://hdl.handle.net/10564/3924
ISSN: 09411291
Academic Degrees and number: 24601B1498
Degree-granting date: 2021-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2020年度

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