小児における血液生化学検査データの性別および年齢別臨床参考範囲

Abstract

Sex- and age-related changes in clinical reference ranges (CRR) of labora- tory blood chemistry data were studied with children. Serum levels of total protein, albumin and creatinine showed linear increases with aging, but AST and LDH showed linear decreases. Serum phosphate levels began to decrease at about 10 years old. In male children, serum total bilirubin, γ GTP and uric acid levels began to increase at about 10 years old. During early childhood (until the age of six to seven), an increase of ZTT and decreases of A/G ratio, calcium and phosphate levels were found. Serum alkaline phos- phatase activities gradually increased until 10-11 years old in girls and 13 years old in boys, and rapidly decreased thereafter. Considering these patterns of sex- and age-related changes in CRR is important to evaluate precisely clinical laboratory data in children