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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3788

Title: Comparison of redox parameters in ovarian endometrioma and its malignant transformation.
Other Titles: 卵巣チョコレート嚢胞とその悪性転化における酸化抗酸化パラメーターの比較
Authors: Fujimoto, Yoshikatsu
Imanaka, Shogo
Yamada, Yuki
Ogawa, Kenji
Ito, Fuminori
Kawahara, Naoki
Yoshimoto, Chiharu
Kobayashi, Hiroshi
Keywords: ovarian endometrioma
endometriosis-associated ovarian cancer
heme oxygenase-1
total antioxidant capacity
Issue Date: Oct-2018
Publisher: Spandidos Publications
Citation: Oncology letters Vol.16 No.4 p.5257-5264 (2018 Oct)
Abstract: The present study aimed to evaluate the levels of oxidative stress and antioxidant markers in benign endometrioma (OE) and its malignant transformation [endometriosis-associated ovarian cancer (EAOC)] by measuring 8-hydroxy-2-deoxyguanosine (8-OHdG), heme oxygenase-1 (HO-1) and total antioxidant capacity (TAC/Heme-iron) alterations associated with disease progression. Cyst fluid samples from 44 patients with OE and 14 patients with EAOC were studied using an enzyme-linked immunosorbent assay. A χ2 test, t-test and Pearson correlation test were performed using SPSS version 22.0. The cut-off point, sensitivity and specificity of each marker for EAOC diagnosis were evaluated by receiver operating characteristic curve analysis. Cyst fluid 8-OHdG and HO-1 levels in the EAOC group were significantly decreased compared with the OE subjects (P=0.013 and P<0.001, respectively). The levels of TAC/Heme-iron in patients with EAOC were significantly higher compared with those in the OE subjects (P<0.001). The present study demonstrated a positive correlation between 8-OHdG and HO-1 levels (P=0.012). HO-1 exhibited the highest discriminant value for EAOC (Area Under the Curve=0.901). The optimal cut-off point of HO-1 for the diagnosis of EAOC was 2.314 ng/ml, with a sensitivity and specifity of 95.2 and 85.7%, respectively. The present study revealed a clear separation between the overall redox state in OE and EAOC. It was concluded that characteristic alterations in important factors in redox may be helpful for understanding the pathogenesis of the malignant transformation of endometriosis.
Description: 博士(医学)・乙第1472号・令和2年9月30日
Copyright © 2018, Spandidos Publications
Articles from Oncology Letters are provided here courtesy of Spandidos Publications.
The publication is available at Spandidos Publications via https://doi.org/10.3892/ol.2018.9242
URI: http://hdl.handle.net/10564/3788
ISSN: 17921074
Academic Degrees and number: 24601B1472
Degree-granting date: 2020-09-30
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2020年度

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