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01121 Journal of Nara Medical Association >
Vol.71 No.1,2,3 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/3773
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Title: | がん性サルコペニアに対する栄養介入 |
Other Titles: | Nutritional intervention against cancer-derived sarcopenia. |
Authors: | 森, 拓也 川原, 勲 額賀, 翔太 宮川, 良博 後藤, 桂 大森, 斉 國安, 弘基 |
Keywords: | 悪液質 骨格筋萎縮 栄養介入 |
Issue Date: | 30-Jun-2020 |
Publisher: | 奈良医学会 奈良県立医科大学 |
Citation: | Journal of Nara Medical Association Vol.71 No.1,2,3 p.01-05 (2020.06) |
Abstract: | Most patients with advanced cancer develop skeletal muscle atrophy called sarcopenia, which reduces treatment tolerance and social activity and worsens the prognosis. Glucose suppresses skeletal muscle atrophy in cancer-bearing mice, while promoting cancer growth. In contrast, medium-chain fatty acids reduce skeletal muscle atrophy and suppress cancer growth. Simultaneous administration of glucose and medium-chain fatty acids suppresses skeletal muscle atrophy and eliminates the tumor growth seen with glucose. Based on these findings, dietary intervention using a combination of glucose and medium-chain fatty acids is expected to be effective in suppressing sarcopema in cancer patients. |
URI: | http://hdl.handle.net/10564/3773 |
Appears in Collections: | Vol.71 No.1,2,3
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