糖負荷が腫瘍成長と骨格筋萎縮におよぼす影響の検討

Abstract

Skeletal muscle volume is reported to be associated with prognosis of cancer patients. Maintenance of skeletal muscle is an essential issue in cancer treatment. Glucose metabolism plays a pivotal role in maintaining skeletal muscle; however, cancer cells also require glucose as a main energy source. We here examined the effect of glucose loading on tumor growth and muscle maintenance using a mouse subcutaneous tumor model. CT26 murine colon cancer cells were inoculated into the subcutaneous tissues in syngenetic BALB/c mice, which were treated with water, 10% glucose or 50% glucose by free drinking for 2 weeks. Blood sugar was not different among the groups. Tumor sizes were larger in the glucose-treated groups than those in the control group. Protein content in the muscle was not different among the groups, whereas the levels of SDS-soluble myosin light chain 1 protein were higher in the glucosetreated groups than those in the control group. These findings suggest that glucose loading enhances muscle differentiation as significant as tumor growth.