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01121 Journal of Nara Medical Association >
Vol.70 No.4,5,6 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3767

Title: 糖負荷が腫瘍成長と骨格筋萎縮におよぼす影響の検討
Other Titles: Effect of Glucose Loading on Cancer Growth and Skeletal Muscle Atrophy.
Authors: 森, 拓也
額賀, 翔太
宮川, 良博
後藤, 桂
川原, 勲
國安, 弘基
Keywords: sugar load
skeletal muscle atrophy
cancer growth
Issue Date: 30-Nov-2019
Publisher: 奈良医学会
奈良県立医科大学
Citation: Journal of Nara Medical Association Vol.70 No.4,5,6 p.57-61 (2019.11)
Abstract: Skeletal muscle volume is reported to be associated with prognosis of cancer patients. Maintenance of skeletal muscle is an essential issue in cancer treatment. Glucose metabolism plays a pivotal role in maintaining skeletal muscle; however, cancer cells also require glucose as a main energy source. We here examined the effect of glucose loading on tumor growth and muscle maintenance using a mouse subcutaneous tumor model. CT26 murine colon cancer cells were inoculated into the subcutaneous tissues in syngenetic BALB/c mice, which were treated with water, 10% glucose or 50% glucose by free drinking for 2 weeks. Blood sugar was not different among the groups. Tumor sizes were larger in the glucose-treated groups than those in the control group. Protein content in the muscle was not different among the groups, whereas the levels of SDS-soluble myosin light chain 1 protein were higher in the glucosetreated groups than those in the control group. These findings suggest that glucose loading enhances muscle differentiation as significant as tumor growth.
URI: http://hdl.handle.net/10564/3767
ISSN: 13450069
Appears in Collections:Vol.70 No.4,5,6

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