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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3759

Title: Potential role of the PD-L1 expression and tumor-infiltrating lymphocytes on neuroblastoma.
Other Titles: 神経芽腫におけるPD-L1発現と腫瘍組織浸潤リンパ球の潜在的役割について
Authors: Zuo, Shogo
Sho, Masayuki
Sawai, Toshio
Kanehiro, Hiromichi
Maeda, Kosaku
Yoshida, Makiko
Tsukada, Ryo
Nomura, Motonari
Okuyama, Hiroomi
Keywords: Neuroblastoma
PD-L1
Tumor-infiltrating lymphocytes
Recurrence
Issue Date: Feb-2020
Publisher: Springer Nature
Citation: Pediatric surgery international Vol.36 No.2 p.137-143 (2020 Feb)
Abstract: Purpose: The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway has garnered much attention for its roles in clinical oncology. The aim of this study was to examine the clinical impact of the PD-L1 expression and tumor-infiltrating lymphocytes (TILs) on neuroblastoma. Methods: We evaluated the PD-L1 expression and TIL status in 31 patients with neuroblastoma who underwent a biopsy or resection by an immunohistochemical analysis. Furthermore, we performed the serial analysis of the PD-L1 status before and after chemotherapy in 15 patients. Results: Among the 31 cases, 11 (35%) showed a positive PD-L1 expression. The survival analysis showed a trend toward an association between PD-L1 positivity and a decreased overall survival. PD-L1 positivity tended to be associated with higher levels of tumor markers. In the serial analysis of the PD-L1 status, positivity was noted in 8 of 15 patients before chemotherapy and 6 after chemotherapy. Notably, all four patients with a positive PD-L1 status both before and after chemotherapy had recurrence, and 3 of them died during the follow-up period. Conclusion: Our findings suggest that the PD-L1 tumor expression might be a good biomarker for the treatment of neuroblastoma patients, especially for advanced neuroblastoma.
Description: 博士(医学)・乙第1458号・令和2年6月30日
© Springer-Verlag GmbH Germany, part of Springer Nature 2020
This is a post-peer-review, pre-copyedit version of an article published in Pediatric surgery international. The final authenticated version is available online at: http://doi.org/10.1007/s00383-019-04616-9.
発行元が定める登録猶予期間終了の後、本文を登録予定(2021.02)
URI: http://hdl.handle.net/10564/3759
ISSN: 01790358
Academic Degrees and number: 24601B1458
Degree-granting date: 2020-06-30
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2020年度

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